The San Francisco 49ers are preparing for their Week 11 contest against the Arizona Cardinals on Sunday at State Farm Stadium in Glendale, Arizona. Both teams have released their official injury reports, which are provided below.
San Francisco 49ers
Questionable- CB Deommodore Lenoir (calf)
Arizona Cardinals
Out- LB Baron Browning (concussion)
- G Hayden Conner (knee)
- WR Marvin Harrison (illness)
- CB Will Johnson (back, hip)
- S Dadrion Taylor-Demerson (ankle)
- T Jonah Williams (shoulder)
- LB Mack Wilson (ribs)
Questionable
- T Kelvin Beachum (not injury related - resting player, groin)
- G Will Hernandez (knee)
- RB Zonovan Knight (ankle)
- DT Walter Nolen (knee)
- LB B.J. Ojulari (knee)
- DT Darius Robinson (groin)
Injury Notes
The biggest takeaway from Friday's 49ers practice was the absence of cornerback Deommodore Lenoir, who first appeared on Thursday's injury report with a calf issue. He's listed as questionable for Sunday's game.
Head coach Kyle Shanahan confirmed Lenoir's injury occurred during practice on Thursday.
"He tried to go today, didn't," Shanahan said. "He'll get an MRI here. Didn't think it was that serious. Did a jog-in from a drill—just some tightness. We'll find more when we get an MRI."
Brock Purdy is set to return as the starting quarterback after participating fully in practice on Thursday and Friday. Sunday will mark his first game action since Week 4, when he aggravated a turf toe injury.
"I thought it was an awesome week for him," Shanahan said. "Just getting back to do what he does, do what we do, and do it aggressively."
QB1 back at it 😈 pic.twitter.com/a0fOMFp6Y0
— 49ers on NBCS (@NBCS49ers) November 14, 2025
Wide receiver Ricky Pearsall also looks set to play for the first time since Week 4, when he suffered a knee injury.
Additionally, rookie defensive tackle Alfred Collins, who missed Week 10 with a hip injury, has been cleared to play against the Cardinals.
Below are Friday's practice participation reports for both the 49ers and Cardinals, which were provided by the 49ers Communications staff.
San Francisco 49ers Friday Practice
Did Not Participate In Practice- CB Deommodore Lenoir (calf)
Full Participation in Practice
- DT Alfred Collins (hip)
- QB Mac Jones (knee, knee)
- RB Christian McCaffrey (not injury related - resting player)
- WR Ricky Pearsall (knee)
- QB Brock Purdy (toe)
- T Trent Williams (not injury related - resting player)
- LB Dee Winters (knee, knee)
Arizona Cardinals Friday Practice
Did Not Participate In Practice- LB Baron Browning (concussion)
- DT Calais Campbell (not injury related - resting player)
- WR Marvin Harrison (illness)
- CB Will Johnson (back, hip)
- S Dadrion Taylor-Demerson (ankle)
- T Jonah Williams (shoulder)
- LB Mack Wilson (ribs)
Limited Participation in Practice
- T Kelvin Beachum (not injury related - resting player, groin)
- G Hayden Conner (knee)
- G Will Hernandez (knee)
- RB Zonovan Knight (ankle)
- DT Walter Nolen (knee)
- LB B.J. Ojulari (knee)
- DT Darius Robinson (groin)
- LB Josh Sweat (not injury related - resting player, knee)
Full Participation in Practice
- G Evan Brown (foot)
- CB Max Melton (concussion)
- WR Xavier Weaver (ankle)