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49ers open as home underdogs vs. division rival Rams in Week 10
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49ers vs. Rams in Week 10: How to watch, stream, and listen, plus odds
49ers vs. Rams in Week 10: How to watch, stream, and listen, plus odds
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Nov 5, 2025
The San Francisco 49ers return to Levi's Stadium to face the Los Angeles Rams in the second of two matchups this season. This marks the 154th all-time meeting between the two teams. The 49ers lead the series 79-71-3 and aim to improve their home record to 38-36-2 against the...
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