The San Francisco 49ers will take on the Jacksonville Jaguars in the second of back-to-back games at Levi's Stadium. This matchup marks the eighth all-time meeting between the two teams, with the 49ers leading the series 5-2 and aiming to improve to 3-0 at home against Jacksonville.
Previous game
The 49ers are coming off a 16-15 victory over the Arizona Cardinals, highlighted by kicker Eddy Piñeiro converting his lone extra point and all three field goal attempts, including the game-winning 35-yarder as time expired. Quarterback Mac Jones led the offense, completing 27 of 41 passes for 284 yards and one touchdown. Wide receiver Ricky Pearsall hauled in eight catches for a team-high 117 yards, while wideout Kendrick Bourne added four receptions for 38 yards. Fullback Kyle Juszczyk contributed a one-yard touchdown reception, and running back Christian McCaffrey posted 17 carries for 52 yards along with 10 receptions for 88 yards.
Defensively, San Francisco held the Cardinals to just 260 total yards of offense. Linebacker Fred Warner paced the unit with a team-high 11 tackles and two passes defensed. Linebacker Dee Winters matched his career high with eight tackles and added one pass breakup. Defensive lineman Nick Bosa registered two tackles and a forced fumble, while defensive lineman Bryce Huff chipped in five tackles and a sack of quarterback Kyler Murray.
The 49ers Communications staff provided the above breakdown.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Sunday, September 28 at 1:05 p.m. PT
Where is the game being played?
Levi's Stadium in Santa Clara, California
Who are the head coaches?
49ers: Kyle Shanahan
Jaguars: Liam Coen
Betting Odds
As of September 24, the 49ers are favored by three points in this game, with an over/under set at 47 points, per BetMGM.
What channel is the game on?
Network: FOX
Play-By-Play: Adam Amin
Color Analyst: Mark Sanchez
Sideline Reporter: Kristina Pink
Viewers outside the broadcast area can watch the game via NFL Sunday Ticket on YouTube TV or YouTube Premium, but a subscription to the package is required.
What areas will receive the broadcast?
The broadcast will be viewable within the markets designated below for those without NFL Sunday Ticket.
Coverage map courtesy of 506sports.com
Where can I stream the game?
NFL Sunday Ticket subscribers can stream the game using the YouTube TV app. Those who purchased through YouTube Premium can watch via the YouTube app. Additionally, NFL+ subscribers can stream the game in its entirety once the matchup has been completed.
Bay Area fans can stream the game through the official 49ers app or at 49ers.com.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.
Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.
Jaguars Radio
Jacksonville area fans can listen on 1010 XL 92.5 FM, where Frank Frangie and Jeff Lageman will call the game.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 7
Series Record: 49ers lead series 5-2
49ers Home Record vs. Jaguars: 49ers lead series 2-0
49ers Away Record vs. Jaguars: 49ers lead series 3-2
First Meeting: 9/12/99, Jaguars win 41-3, at Jax.
Last Meeting: 11/12/23, 49ers win 34-3, at Jax.
Current Streak: Won 5
Longest 49ers Win Streak: 5 (11/29/09 - current)
Longest Jaguars Win Streak: 2 (9/12/99 – 12/18/05)
Most 49ers Points: 44 (12/24/17): 49ers win 44-33, at SF
Most Jaguars Points: 41 (9/12/99): Jaguars win 41-3, at Jax.
49ers Shutouts: None
Jaguars Shutouts: None
49ers Notes
- QB Brock Purdy passed for 296 yards and 3 TDs with 0 INTs for a 148.9 rating in the last meeting. Has 2+ TD passes in each of his past 3 starts.
- QB Mac Jones aims for his 3rd in a row with 275+ pass yards and a TD pass. Appeared in 10 games (7 starts) with Jacksonville in 2024, totaling 1,672 pass yards and 9 TDs (8 pass, 1 rush). Posted 3 TDs and 0 INTs with a 128.1 rating in his only career start vs. Jacksonville (1/2/22 with New England).
- RB Christian McCaffrey had 10 receptions and 140 scrimmage yards (88 receiving, 52 rushing) in Week 3, his 12th career game with 10+ catches—the most by an RB in NFL history. Leads all RBs with 25 receptions and ranks 3rd in the NFL with 389 scrimmage yards in 2025. Has 379 scrimmage yards (189.5 per game) and 3 TDs (2 rush, 1 rec.) in 2 career games vs. Jacksonville. Aims for his 4th in a row with 50+ rush yards and 50+ receiving yards.
- FB Kyle Juszczyk recorded his 19th career receiving TD last week. Has a TD catch in 3 of his past 5 games and scored in the last meeting.
- WR Ricky Pearsall tied his career high with 8 receptions and had 117 receiving yards in Week 3, his 3rd career 100-yard game. Aims for his 6th in a row with 50+ receiving yards.
- WR Jauan Jennings has 5+ receptions and 50+ receiving yards in 3 of his past 4 games.
- LB Fred Warner led the team with 11 tackles and 2 passes defended last week. Since 2018, leads all LBs with 56 PD. Has a TFL in 4 of his past 5 games. Had an INT in the last meeting.
- LB Dee Winters aims for his 7th in a row with 6+ tackles.
- DL Bryce Huff recorded his 22nd career sack last week and aims for his 3rd in a row with a sack.
- DL Mykel Williams leads all rookies with 3 TFL and aims for his 3rd in a row with a TFL.
- CB Upton Stout (rookie) has a PD in 2 of 3 career games.
- CB Deommodore Lenoir aims for his 3rd in a row with a TFL.
Jaguars Notes
- QB Trevor Lawrence aims for his 3rd in a row with 220+ pass yards. Has 2+ TD passes in 3 of his past 4 road starts.
- RB Travis Etienne recorded 56 rush yards and his 1st rushing TD of the season last week. Aims for his 6th in a row with 55+ scrimmage yards and 3rd straight with a TD. One of 6 NFL players with both a rushing and receiving TD this season.
- RB Bhayshul Tuten (rookie) scored his 1st career rushing TD in Week 3. Aims for his 3rd in a row with a TD. Also, 1 of 6 NFL players with both a rushing and receiving TD this season.
- WR Brian Thomas Jr. posted a season-high 55 receiving yards last week. Has 5+ catches and 80+ receiving yards in 4 of his past 5 road games. Needs 6 catches for his 100th career reception.
- WR Parker Washington aims for his 3rd in a row with 4+ receptions. Has 50+ receiving yards in 2 of his past 3 road games.
- TE Brenton Strange led the team with season highs in receptions (6) and receiving yards (61) last week. Has 55+ receiving yards in 3 of his past 4.
- WR/DB Travis Hunter (rookie) recorded a season-high 6 tackles last week.
- DE Josh Hines-Allen registered 0.5 sack and a PD in Week 3.
- DT Arik Armstead aims for his 3rd in a row with 0.5+ sacks. Has a sack in 2 of his past 3 road games. Facing San Francisco for the 1st time after spending his first 9 seasons (2015–23) with the team, totaling 33.5 career sacks.
- LB Foyesade Oluokun aims for his 9th in a row with 5+ tackles. Has a PD in 2 of his past 3 games. Recorded 9 tackles, 3 TFL, and 2 sacks in the last meeting.
- DE Travon Walker aims for his 3rd in a row with a sack. Had a PD in the last meeting.
- CB Tyson Campbell led the team with 7 tackles and added a PD and his 3rd career forced fumble in Week 3. One of 4 NFL players with 5+ tackles and a PD in each of the first 3 weeks.
- CB Jourdan Lewis had 2 PD and his 2nd INT of the season last week. Aims for his 5th in a row with a PD. Leads the NFL with 6 PD this season.
- S Antonio Johnson recorded his 3rd career INT in Week 3.
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