The injury bug bit the San Francisco 49ers yet again in a major way, with defensive end Nick Bosa lost for the season to a torn ACL.
Nick Bosa injury update: 49ers DE out for season with torn ACL
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Report: 49ers DE Nick Bosa suffered season-ending torn ACL
By David Bonilla
Sep 22, 2025
The San Francisco 49ers will continue the season without their star pass rusher, Nick Bosa. ESPN's Adam Schefter reports that the defensive end suffered a season-ending torn ACL late in the first quarter of Sunday's 16-15 victory over the Arizona Cardinals at Levi's...
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