The depleted 49ers once again turned to Mac Jones, and he, once again, helped deliver a win. After practicing all week in a limited capacity, San Francisco opted to err on the side of caution and let Brock Purdy recover from his toe injury for another week. Neither the 49ers nor the Cardinals’ offense came out of the gates firing, as both teams matched field goals in the second quarter before San Francisco took a 6-3 lead into halftime after Eddy Piñeiro’s second make of the game.San Francisco, already without star players such as Purdy, wide receivers Jauan Jennings and Brandon Aiyuk, plus tight end George Kittle, suffered additional injuries on Sunday after Nick Bosa left the game in the first quarter with a knee injury and did not return, while rookie defensive lineman Mykel Williams departed shortly after with a wrist injury and did return. Bosa is questionable to return : @NFLonFOX https://t.co/iM7OL3xKgq pic.twitter.com/bqf6ub0ucQ — 49ers on NBCS (@NBCS49ers) September 21, 2025 Both offense continued to struggle throughout the second and third quarters before San Francisco’s broke through midway through the fourth with a...
What we learned as Eddy Piñeiro walk-off FG seals 49ers’ win vs. Cardinals
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