Here's everything you need to know for Week 2 NFL games. Which teams will win, who are the X factors, and which storylines matter most?
Our guide to every Week 2 NFL game: Matchup previews, predictions, picks and nuggets
Published Sep 12, 2025 at 4:20 AM
The above videos are auto-populated by an affiliate.
The above link leads to an external page. 49ers Webzone has no control over its contents.
Follow us on:
Read Next
Latest
- Netflix to stream 49ers vs. Rams Week 1 international showdown in Australia
- 49ers rookie Kaelon Black addresses draft backlash
- Vikings request interview with 49ers' RJ Gillen for GM job
- Will 49ers rookie De'Zhaun Stribling outplay his draft value in 2026?
- 49ers free agency targets: How San Francisco could use its NFL-leading cap space
Trending News
-
49ers Webzone • May 6
-
49ers Webzone • May 5
-
49ers Webzone • May 4
-
SFGate • May 5
-
49ers Webzone • May 4
-
49ers Webzone • May 4