Five 49ers to watch in Week 1 showdown vs. Seahawks as 2025 NFL season kicks off

Published Sep 5, 2025 at 8:20 AM
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Coming off a 6-11 season and last-place finish in the NFC West, the 49ers know the importance of getting off to a fast start.And in an ultra-balanced division, nothing figures to come easy.The 49ers have 10 rookies on their 53-man roster, so they will need immediate contributions from their youngsters. However, the 49ers will go as far as their veteran nucleus will take them.The 49ers’ mix of inexperience and veteran stars will receive a big test against the Seahawks, who finished out of the playoff picture last season despite a 10-7 record in Mike Macdonald’s first season as head coach.Here are five 49ers to watch on Sunday when the NFC West rivals kick off the regular season:CB Deommodore LenoirIf last year was cornerback Deommodore Lenoir’s breakout season, this could be his chance to take his game to an even higher level.Lenoir earned a lucrative contract extension last season but was shut out on All-Pro or Pro Bowl honors. He might need to improve on his takeaway numbers to get more national recognition.Lenoir will not face the interesting challenges of past 49ers-Seahawks games before DK Metcalf is now a member of the Pittsburgh Steelers. But this is not an...

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