The San Francisco 49ers open the 2025 regular season on the road against the Seattle Seahawks at Lumen Field. This matchup marks the 55th all-time meeting between the two teams and only the third time in series history that they have faced off in Week 1. The Niners will be looking for their fourth consecutive victory at Lumen Field.
The Seahawks currently lead the all-time series 31-23, but the 49ers have won five of the last six regular-season meetings. This game also marks the first time San Francisco has opened a season in Seattle since Week 1 of the 2010 season.
San Francisco finished the preseason with a 2-1 record. Offensively, the team averaged 263.0 yards per game, scored 20.3 points per game, and posted 4.4 yards per play. On defense, the Niners limited opponents to 320.0 yards per game and 24.0 points per game.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Sunday, September 7 at 1:05 p.m. PT
Where is the game being played?
Lumen Field in Seattle, Washington
Who are the head coaches?
49ers: Kyle Shanahan
Seahawks: Mike Macdonald
Betting Odds
As of September 3, the 49ers are favored by 2.5 points in this game, with an over/under set at 43.5 points, per BetMGM.
What channel is the game on?
Network: FOX
Play-By-Play: Joe Davis
Color Analyst: Greg Olsen
Sideline Reporter: Pam Oliver
Viewers outside the broadcast area can watch the game via NFL Sunday Ticket on YouTube TV or YouTube Premium, but a subscription to the package is required.
What areas will receive the broadcast?
The broadcast will be viewable within the markets designated below for those without NFL Sunday Ticket.
Coverage map courtesy of 506sports.com
Where can I stream the game?
NFL Sunday Ticket subscribers can stream the game using the YouTube TV app. Those who purchased through YouTube Premium can watch via the YouTube app. Additionally, NFL+ subscribers can stream the game in its entirety once the matchup has been completed.
Bay Area fans can stream the game through the official 49ers app or at 49ers.com.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.
Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.
Seahawks Radio
Seattle area fans can listen on Seattle Sports 710 AM and KIRO 97.3 FM, where Steve Raible and Dave Wyman will call the game.
National Radio
Fans can listen via ESPN Radio, where Jorge Sedano and Kelly Stouffer will call the game.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 54
Series Record: Seahawks lead series 31-23
49ers Home Record vs. Seahawks: Seahawks lead series 14-12
49ers Away Record vs. Seahawks: Seahawks lead series 17-11
First Meeting: 9/26/76, 49ers win 37-21, at Sea.
Last Meeting: 11/17/24, Seahawks win 20-17, at SF
Current Streak: Lost 1
Longest 49ers Win Streak: 6 (9/18/22 – 10/10/24)
Longest Seahawks Win Streak: 10 (1/19/14 – 12/2/18)
Most 49ers Points: 41 (1/14/23): 49ers win 41-23, at SF (w)
Most Seahawks Points: 43 (12/2/18): Seahawks win 43-16, at Sea.
49ers Shutouts: None
Seahawks Shutouts: 2 (Last 11/12/07), Seahawks win 24-0, at Sea.
(w) - Wild Card Game
49ers Notes
- QB Brock Purdy passed for 3,864 yards with 25 total TDs (20 passing, 5 rushing) and a 96.1 rating in 2024. Posted 300+ pass yards and 2+ TD passes in 3 of his final 4 games last season. Has 10 total TDs (9 pass, 1 rush) with a 108.4 rating in 5 career starts vs. Seattle.
- RB Christian McCaffrey has 948 scrimmage yards (158 per game) and 7 TDs (6 rush, 1 rec.) in 6 career games vs. Seattle, with 100+ scrimmage yards in every matchup. Has 3,581 scrimmage yards (115.5 per game) and 31 TDs (20 rush, 11 rec.) in 31 regular-season games with San Francisco since 2022.
- RB Brian Robinson makes his 49ers debut. Recorded 958 scrimmage yards (career-high 799 rush, 159 rec.) and a career-high 8 rushing TDs in 2024. Posted a career-best 157 scrimmage yards (119 rec., 38 rush) and a TD catch in his only career game vs. Seattle (11/12/23).
- TE George Kittle ranked T-2nd among TEs in receiving TDs (8), 3rd in receiving yards (1,106), and 5th in receptions (78) last season. One of five TEs all-time with 1,000+ receiving yards in 4 career seasons. Has 7 receiving TDs in his past 5 games vs. Seattle.
- WR Jauan Jennings set career highs with 77 receptions, 975 yards, and 5 TDs in 2024. Had 10 catches for 91 yards and a TD in the last meeting.
- LB Fred Warner is 1 of 2 players (alongside Bobby Wagner) with 115+ tackles in each of the past 7 seasons. Had 11 tackles in his last road game at Seattle.
- DL Nick Bosa has recorded 45+ tackles, 9+ sacks, and 15+ TFLs in 5 of his 6 career seasons. Has 10 sacks in his past 8 games vs. Seattle.
- DL Mykel Williams was selected No. 11 overall in the 2025 NFL Draft.
- DL Alfred Collins was selected in the 2nd round (No. 43 overall) of the 2025 NFL Draft.
- CB Renardo Green ranked T-2nd among rookies with 13 passes defensed in 2024.
- CB Deommodore Lenoir posted a career-high 85 tackles last season.
- S Ji'Ayir Brown tallied 77 tackles, 6 passes defensed, and 3 tackles for loss in 2024.
- S Jason Pinnock makes his 49ers debut. Recorded 85 tackles in each of the past 2 seasons with the Giants.
Seahawks Notes
- QB Sam Darnold makes his Seahawks debut. Set career highs in passing yards (4,319), TD passes (35), and rating (102.5) in 2024 with Minnesota. Passed for 268 yards and 2 TDs with a 109.1 rating in his last start vs. San Francisco (9/15/24 with MIN). Spent the 2023 season with the 49ers.
- RB Kenneth Walker III posted a career-high 46 catches with 872 scrimmage yards (573 rush, career-high 299 rec.) and 8 TDs (7 rush, 1 rec.) in 2024. One of 5 RBs with 8+ scrimmage TDs in each of the past 3 seasons. Scored a rushing TD in both games vs. SF last year.
- RB Zach Charbonnet recorded career highs in receptions (42), scrimmage yards (909 — 569 rush, 340 rec.), and total TDs (9 — 8 rush, 1 rec.) in 2024.
- WR Jaxon Smith-Njigba set career bests with 100 receptions, 1,130 yards, and 6 TDs in 2024. Had 10 catches for 110 yards in the last meeting vs. SF.
- WR Cooper Kupp makes his Seahawks debut. Totaled 634 receptions, 7,915 scrimmage yards, and 58 TDs (57 rec., 1 rush) in 104 games (2017–24) with the Rams.
- DE Leonard Williams posted career highs with 16 TFLs and 11 sacks in 2024. Recorded 2+ sacks in 4 of his final 7 games last season, including Weeks 17–18.
- DE DeMarcus Lawrence makes his Seahawks debut. Registered 97 TFLs, 61.5 sacks, 21 forced fumbles, and 20 passes defensed in 141 games (2014–24) with Dallas.
- LB Ernest Jones had 138 tackles (with TEN & SEA) in 2024, his 3rd straight 100+ tackle season. Tallied 13 tackles in the last meeting vs. SF.
- LB Tyrice Knight recorded 6+ tackles in 7 of his final 8 games in 2024, including 10 tackles in the last meeting vs. SF.
- CB Devon Witherspoon posted career highs with 98 tackles, 9 passes defensed, and 6 TFLs in 2024. Had 3 PDs in the last meeting.
- CB Riq Woolen is the only player since 2022 with 40+ passes defensed (41) and 10+ INTs (11).
- S Julian Love had 106 tackles, a career-high 12 passes defensed, and 3 INTs in 2024. One of 2 DBs (alongside Kevin Byard) with 100+ tackles in each of the past 3 seasons.