SANTA CLARA - The 49ers could start their fifth running back of the 2924 NFL season season in Sunday's game against the Miami Dolphins. Rookie Isaac Guerendo sat out of a second consecutive practice Thursday due to a hamstring injury, placing his availability for the Week 16 contest in jeopardy. The team already is without Christian McCaffrey, Jordan Mason, and Elijah Mitchell. Patrick Taylor is set to receive the starting role if Guerendo is not healthy enough to play. Behind Taylor are Ke'Shawn Vaughn and Israel Abanikanda, who also could see some playing time. While this could be shocking to some teams, coach Kyle Shanahan had six different leading rushers across his first six seasons with the 49ers, so a variety of ball carriers is nothing new for San Francisco. Trent Williams remained absent from the practice field Thursday with an ankle injury, which makes swing tackle Jaylon Moore likely to receive his fifth consecutive start at left tackle in Miami. Nick Bosa's availability also is in question after he practiced in a limited fashion on Wednesday. The All-Pro edge rusher sat out of practice on Thursday, which is traditionally the team's heavier work day. Safety Malik...
49ers-Dolphins practice report: Bosa, Guerendo sit out Thursday
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