The San Francisco 49ers hit the road for the second consecutive week to face the Buffalo Bills on Sunday Night Football at Highmark Stadium. This matchup marks the 14th all-time meeting between the two teams and the first since the 2020 season. San Francisco aims to improve to 7-7 in the series against Buffalo and 3-0 against AFC East opponents in 2024.
Previous game
The 49ers are coming off a 38-10 loss to the Green Bay Packers. On offense, the Niners were led by tight end George Kittle, who caught all six of his targets for a team-high 82 yards and one touchdown. Quarterback Brandon Allen completed 17 of 29 passing attempts for 199 yards. Wide receiver Jauan Jennings contributed five receptions for 40 yards, while running back Christian McCaffrey added 11 carries for 31 yards on the ground and three receptions for 37 yards.
Defensively, defensive lineman Leonard Floyd recorded four tackles and 2.0 sacks against Packers quarterback Jordan Love. Cornerback Isaac Yiadom and safety Malik Mustapha each registered nine tackles, providing critical support for the 49ers' defense.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Sunday, December 1 at 5:20 p.m. PT
Where is the game being played?
Highmark Stadium in Orchard Park, New York
Who are the head coaches?
49ers: Kyle Shanahan
Bills: Sean McDermott
Betting Odds
As of November 26, the Bills are favored by seven points in this game, with an over/under set at 45 points.
What channel is the game on?
Network: NBC
Play-By-Play: Mike Tirico
Color Analyst: Cris Collinsworth
Sideline Reporter: Melissa Stark
What areas will receive the broadcast?
NBC will broadcast the game nationally.
Where can I stream the game?
You can watch the matchup live on the NBC website, NBC Sports app, NBC Sports website, Peacock TV, or the NBC app. Sunday Night Football will also be available to watch on the Yahoo Sports app and NFL app.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Greg Papa and Tim Ryan will call the game.
Jesu?s Za?rate and Carlos Yustis will call the game in Spanish. That broadcast can be heard at 49ers.com/news/Espanol.
Bills Radio
Buffalo area fans can listen on WGR 550, where Chris Brown and Eric Wood will call the game.
National Radio
Fans can listen via Westwood One, where Ryan Radtke and Ross Tucker will call the game.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 13
Series Record: Bills lead series 7-6
49ers Home Record vs. Bills: Series is tied 4-4
49ers Away Record vs. Bills: Bills lead series 3-2
First Meeting: 9/24/72, Bills win 27-20, at Buf.
Last Meeting: 12/7/20, Bills win 34-24, at SF*
Current Streak: Lost 2
Longest 49ers Win Streak: 2 - 2 times (Last 11/30/08 – 10/7/12)
Longest Bills Win Streak: 2 - 2 times (Last 10/16/16 – 12/7/20)
Most 49ers Points: 45 (10/7/12): 49ers win 45-3, at SF
Most Bills Points: 45 (10/16/16): Bills win 45-16, at Buf.
49ers Shutouts: 12/2/01, 49ers win 35-0, at SF
Bills Shutouts: None
SF* - State Farm Stadium (Arizona)
49ers Notes
- QB Brock Purdy has 32 total touchdowns (31 passing, 1 rushing) versus six interceptions, with a 113.1 passer rating in 15 career regular-season road starts. He can become the fourth player ever (joining Tom Brady, Carson Palmer, and Russell Wilson) with a 100+ passer rating in eight consecutive road starts.
- QB Brandon Allen threw for 199 yards and one touchdown with one interception in his first start of the season in Week 12. He has a touchdown pass in eight of his 10 career starts.
- RB Christian McCaffrey totaled 68 scrimmage yards (37 receiving, 31 rushing) in Week 12 and has recorded 50+ scrimmage yards in 25 consecutive games, the longest active streak in the NFL. He has 15 touchdowns (10 rushing, 5 receiving) in 15 road games with San Francisco.
- TE George Kittle had six receptions for 82 yards and his eighth touchdown catch of the season last week, leading all tight ends in receiving touchdowns in 2024. He aims for his fourth straight game overall and fifth straight road game with a touchdown catch. With 509 career receptions and 6,916 receiving yards, Kittle is poised to become the third tight end in NFL history (joining Antonio Gates and Travis Kelce) to surpass 500 receptions and 7,000 receiving yards in their first eight seasons.
- WR Deebo Samuel has 511 receiving yards in 2024, marking his fifth career season with 500+ receiving yards. He has 60+ receiving yards in three of his four road games this season.
- WR Jauan Jennings had five catches last week and aims for his fourth consecutive game with 5+ receptions. He has set career highs in receptions (47) and receiving yards (628) in 2024.
- LB Fred Warner has 84 tackles in 2024 and is one of six players with 80+ tackles in each of the past seven seasons. He recovered a fumble in the last meeting between these teams.
- DL Nick Bosa aims for his fourth consecutive game with a sack.
- DL Leonard Floyd recorded two sacks last week and looks to extend his streak to three consecutive games with at least 1.5 sacks. He has 10.5 sacks and nine tackles for loss in 2024 with San Francisco.
- CB Renardo Green (rookie) aims for his fourth straight game with a pass defended (PD).
- S Malik Mustapha (rookie) had his second tackle for loss (TFL) of the season last week and aims for his sixth consecutive game with 5+ tackles.
Bills Notes
- BILLS can achieve seven consecutive regular-season wins in a single season for the fifth time in franchise history (previously accomplished in 2022, 1990, 1988, and 1964).
- QB Josh Allen totaled 317 yards (262 passing, 55 rushing) and two touchdowns (one passing, one rushing) in Week 11, marking his 39th career game with both a passing and rushing touchdown—the second-most all-time. He aims for his third consecutive game with 250+ passing yards and 50+ rushing yards. Allen has thrown 2+ touchdown passes with a 95+ passer rating in four of five home games this season. In the last meeting, he passed for 375 yards and four touchdowns with no interceptions, earning a 139.1 rating. Allen holds a 6-2 record in eight career starts on Sunday Night Football (SNF).
- RB James Cook rushed for two touchdowns in Week 11 and is one of four running backs with 2+ rushing touchdowns in three or more games this season. He has scored a rushing touchdown in five of his past six games and aims for his fifth consecutive game against NFC opponents with 100+ scrimmage yards. Cook has four total touchdowns (three rushing, one receiving) in his past three primetime games. He ranks tied for fourth in the NFL with 10 rushing touchdowns, becoming the first Bills running back with 10+ rushing touchdowns in a season since LeSean McCoy (13 in 2016).
- WR Khalil Shakir led the team with eight receptions for 70 yards in Week 11. He aims for his sixth consecutive game with 6+ receptions and 50+ receiving yards.
- WR Amari Cooper recorded 55 receiving yards in Week 11. He had 108 receiving yards in his last game against San Francisco (October 15, 2023, with Cleveland) and aims for his third consecutive SNF game with a receiving touchdown.
- WR Curtis Samuel set season highs in catches (5) and receiving yards (58) while recording his first touchdown reception of the season in Week 11. He looks to extend his streak to three games with 4+ receptions.
- LB Terrel Bernard tallied eight tackles, his first sack of the season, and his second interception in Week 11. He aims for his fifth consecutive game with 8+ tackles and his third straight game with a pass defended.
- LB Von Miller recorded his fourth sack of the season in Week 11. He has seven tackles for loss (TFL) and four sacks in four career games against San Francisco. Miller boasts 15 sacks in 21 career games on SNF.
- LB Dorian Williams has recorded 9+ tackles in two of his past three games.
- S Taylor Rapp had six tackles and an interception in Week 11. He aims for his seventh consecutive game with 5+ tackles.