49ers vs. Vikings injury report: CMC out Week 2; Hufanga questionable

SANTA CLARA — The 49ers are leaving no doubt this week. Running back Christian McCaffrey was ruled out Friday when the 49ers announced their official injury report for the Week 2 game against the Minnesota Vikings. Coach Kyle Shanahan said the 49ers now are considering placing McCaffrey on injured reserve, which would make him ineligible for the next four games. McCaffrey experienced his most discomfort with his right Achilles tendinitis and calf strain during Thursday's practice, Shanahan said. The 49ers listed safety Talanoa Hufanga and doubtful for the game, and linebacker Dee Winters as questionable on their injury report as questionable for Sunday's game against the Vikings. McCaffrey was sidelined with the condition for most of training camp. The running back strained his calf during practice on Aug. 4 and did not resume on-field work with his teammates until Sept. 3. McCaffrey returned to practice on a limited basis when the 49ers began preparations last week to face the New York Jets in the regular-season opener. He was among the seven players the 49ers listed as inactive before the game to reach the game-day limit of 48 available players. Coach Kyle Shanahan said this...