With Jimmy Garoppolo formally declared out of Sunday's game, Trey Lance, 21, will become the first 49ers rookie quarterback to start a game since C.J. Beathard in 2017. Lance will likely be without All-Pro tight end George Kittle, who is doubtful to play because of a calf injury.
49ers’ Trey Lance will make first NFL start, likely without George Kittle
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49ers-Cardinals Injury Report: Jimmy Garoppolo ruled out for Sunday; George Kittle doubtful
By David Bonilla
Oct 8, 2021
The San Francisco 49ers are preparing for their Week 5 contest against the Arizona Cardinals on Sunday at State Farm Stadium in Glendale, Arizona.
Quarterback Jimmy Garoppolo did not practice this week and has been ruled "out" for Sunday, which means fans will see rookie Trey...
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