The release of the schedule for the first weekend of the 2021 NFL season has led to sportsbooks releasing point spreads for the first 16 games of the year. A pair of NFC West teams have been installed as the biggest early favorites. William Hill has the 49ers favored by seven points in their road [more]
49ers, Rams open as biggest Week One favorites
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49ers open as 7-point Week 1 road favorite vs. Lions
By David Bonilla
May 12, 2021
The entire opening week of the NFL's 2021 schedule has been revealed, and the San Francisco 49ers will head on the road to face the Detroit Lions. BetMGM is already listing the Niners as seven-point favorites against the Lions.
NFL Week 1 lines at @BetMGM are up:DAL @ TB...
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