1 Sep 13 SF @ ARI University of Phoenix Stadium 4:15 FOX - Loss
2 Sep 20 SEA @ SF Candlestick Park 4:05 PM FOX - Win
3 Sep 27 SF @ MIN Hubert H. Humphrey Metrodome 1:00 PM FOX - Loss
4 Oct 04 STL @ SF Candlestick Park 4:15 PM FOX - Win
5 Oct 11 ATL @ SF Candlestick Park 4:05 PM FOX - Loss
6 Bye
7 Oct 25 SF @ HOU Reliant Stadium 1:00 PM FOX - Loss
8 Nov 01 SF @ IND Lucas Oil Stadium 1:00 PM FOX - Loss
9 Nov 08 TEN @ SF Candlestick Park 4:15 PM CBS - Loss
10 Nov 12 CHI @ SF Candlestick Park 8:20 PM NFL NETWORK Thursday Night - Win
11 Nov 22 SF @ GB Lambeau Field 1:00 PM FOX - Loss
12 Nov 29 JAC @ SF Candlestick Park 4:05 PM CBS - Loss
13 Dec 06 SF @ SEA Qwest Field 4:15 PM FOX - Win
14 Dec 14 ARI @ SF Candlestick Park 8:30 PM ESPN Monday Night - Win
15 Dec 20 SF @ PHI Lincoln Financial Field 1:00 PM FOX - Loss
16 Dec 27 DET @ SF Candlestick Park 4:05 PM FOX - Win
17 Jan 03 SF @ STL Edward Jones Dome 1:00 PM FOX - Win
Another 7-9 season