The 49ers will open up the season at home against the Los Angeles Rams as part of a Monday Night Football doubleheader. Then they will head on the road to face the defending NFC Champion Carolina Panthers.
The 49ers have a Thursday night game during week 5 against the Arizona Cardinals at Levi's Stadium, play on Christmas Eve in Los Angeles against the Rams, and will finish the 2016 season at home against the division rival Seattle Seahawks.
Below is the complete 2016 San Francisco 49ers schedule, which can also be found on our official schedule page or even in wallpaper format for your phone.
| Week | Date | Time | Opponent | TV |
| 1 | Mon, Sep 12 | 7:20 pm | Rams | ESPN |
| 2 | Sun, Sep 18 | 10:00 am | at Panthers | FOX |
| 3 | Sun, Sep 25 | 1:05 pm | at Seahawks | FOX |
| 4 | Sun, Oct 2 | 1:25 pm | Cowboys | FOX |
| 5 | Thur, Oct 6 | 5:25 pm | Cardinals | NFLN |
| 6 | Sun, Oct 16 | 10:00 am | at Bills | FOX |
| 7 | Sun, Oct 23 | 1:05 pm | Buccaneers | FOX |
| 8 | BYE | |||
| 9 | Sun, Nov 6 | 1:05 pm | Saints | FOX |
| 10 | Sun, Nov 13 | 1:25 pm | at Cardinals | FOX |
| 11 | Sun, Nov 20 | 1:25 pm | Patriots | CBS |
| 12 | Sun, Nov 27 | 10:00 am | at Dolphins | FOX |
| 13 | Sun, Dec 4 | 10:00 am | at Bears | FOX |
| 14 | Sun, Dec 11 | 1:05 pm | Jets | CBS |
| 15 | Sun, Dec 18 | 1:05 pm | at Falcons | FOX |
| 16 | Sat, Dec 24 | 1:25 pm | at Rams | FOX |
| 17 | Sun, Jan 1 | 1:25 pm | Seahawks | FOX |