Tonight, the 9-1 San Francisco 49ers will face the 7-3 Baltimore Ravens at M&T Bank Stadium in Baltimore, a matchup that features brother versus brother on Thanksgiving.
It will be the first time in NFL history that two brothers have faced each other as head coaches in what is being called "HarBowl" as Jim Harbaugh of the 49ers battles John Harbaugh of the Ravens.
The 49ers are coming off of a 23-7 win over the Arizona Cardinals while the Ravens are coming off of a 31-24 win over the Cincinnati Bengals.
The game kicks off at 5:20 PM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on NFL Network.
In the 49erswebzone.com Pick 'Em Contest, 75% of 49ers fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 66% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.