New San Francisco 49ers head coach Jim Harbaugh leads his squad against the Saints in New Orleans. It is the first chance for fans to see rookies like Colin Kaepernick and Aldon Smith.
The game kicks off at 5:00 PM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be aired locally.
Within Sportstacular, a popular mobile phone scores application, 68% of fans believe that the Saints will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.