The following is the announced San Francisco 49ers 2010 schedule. The dates and times were announced on Tuesday, April 20. All listed times are Pacific.
Preseason
Date TBA - @Colts - Time TBA
Sun 8/22 - Vikings - 5:00pm
Date TBA - @Raiders - Time TBA
Date TBA - Chargers - Time TBA
Regular Season
Sun 9/12 - @Seahawks - 1:15pm
Mon 9/20 - Saints - 5:30pm
Sun 9/26 - @Chiefs - 10:00am
Sun 10/03 - @Falcons - 10:00am
Sun 10/10 - Eagles - 5:20pm
Sun 10/17 - Raiders - 1:15pm
Sun 10/24 - @Panthers - 10:00am
Sun 10/31 - Broncos - 10:00am (London)
BYE
Sun 11/14 - Rams - 1:15pm
Sun 11/21 - Buccaneers - 1:05pm
Mon 11/29 - @Cardinals - 5:30pm
Sun 12/5 - @Packers - 10:00am
Sun 12/12 - Seahawks - 1:05pm
Thur 12/16 - @Chargers - 5:20pm
Sun 12/26 - @Rams - 10:00am
49ers practice and media schedule ahead of Wild Card playoff matchup vs. Eagles
By Site Staff
Jan 6
The San Francisco 49ers will hold three full practices this week as they prepare for their Wild Card playoff matchup against the Philadelphia Eagles.
Head coach Kyle Shanahan, defensive coordinator Robert Saleh, offensive coordinator Klay Kubiak, and quarterback Brock Purdy...
49ers vs. Eagles injury report: San Francisco gets massive boost before playoff clash
By David Bonilla
Jan 8
The San Francisco 49ers are preparing for their Wild Card Round playoff contest against the Philadelphia Eagles on Sunday at Lincoln Financial Field in Philadelphia, Pennsylvania.
Great news for 49ers fans: All-Pro left tackle Trent Williams returned to the practice field,...
San Francisco 49ers opponents for 2026 season announced
By Marc Adams
Jan 4
The 2026 opponents for the San Francisco 49ers have been announced. The 49ers finished third in the NFC West and will play a third-place schedule next season. The 49ers will have nine home games and will go on the road eight times. Here are the 2026 opponents:
Home
Las Vegas...
49ers injury updates: San Francisco enters playoffs with mounting health concerns
By David Bonilla
Jan 3
The San Francisco 49ers battled through injuries all season and still carried a six-game winning streak into their Week 18 matchup against the Seattle Seahawks. With the NFC West title, the No. 1 seed in the NFC playoffs, and home-field advantage at stake, the 49ers fell flat...