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San Francisco 49ers quarterback Jimmy Garoppolo has developed a strong connection with wide receiver Brandon Aiyuk this season, as the third-year wideout leads the team in targets(62), receptions(44), yards(567), and touchdowns(4). After a season in which Garoppolo missed several intermediate routes that Aiyuk ran, especially corner routes between the safeties and linebackers, the two have connected in several ways this season, especially over the middle. Regardless of what route Aiyuk is running, Garoppolo has confidence in his receiver to make the play, especially with his route-running ability that allows him to separate from defenders. "I just run the plays, whatever is called, whatever the route is for him. We just make the best of the

San Francisco 49ers quarterback Trey Lance has been making progress. He was on the sidelines during Monday night's game against the Arizona Cardinals in Mexico City. Lance is out of his protective boot and appears to be walking fine just two months after undergoing surgery to repair the damage sustained from the season-ending right ankle injury. Trey Lance's brother, Bryce, recently shared a video update on the quarterback. Lance can be seen doing some light work, putting pressure on his ankle. Per Bryce Lance's Snapchat, Trey Lance is doing very well! Looks to be doing light jog work in this rehab video. Putting

It was a strange week for the San Francisco 49ers, who had to work through an unusual schedule that saw them arrive home from their Monday night game in Mexico City in the early morning hours on Tuesday, followed by Thanksgiving on Thursday. Still, they managed to work through it and prepare themselves to play against the New Orleans Saints on Sunday, and in the end they came out on top with a 13-0 win. How did the 49ers work through that schedule? We'll look at that in this version of 49ers Notebook, along with some postgame thoughts from head coach Kyle Shanahan on the running back situation, a look at an impressive streak the 49ers snapped on Sunday, and much more. Let's get it started... (See also:

San Francisco 49ers tight end George Kittle had just one catch for 21 yards against the Los Angeles Chargers on Sunday night. It was an impressive effort, though. One person inside the organization even believes it may have been the play that turned everything around in the game for the Niners. The team didn't seem to be clicking for much of the first half. Kittle made the catch and then refused to go down 😤 @gkittle46📺: #LACvsSF on