The San Francisco 49ers head to Indianapolis for their final road trip of the regular season, taking on the Indianapolis Colts at Lucas Oil Stadium on ESPN's Monday Night Football. This matchup marks the 46th all-time meeting between the two teams, with the Colts leading the series 27–18. San Francisco looks to earn its fifth consecutive victory, including its third straight win on the road.
Previous game
The 49ers are coming off a 37–24 home victory over the Tennessee Titans. The offense was led by quarterback Brock Purdy, who completed 23 of 30 passes (76.7 percent) for 295 yards and three touchdowns, posting a passer rating of 140.3. Purdy also added seven rushing attempts for a season-high 44 yards. Wide receiver Jauan Jennings recorded three receptions for 37 yards and two touchdowns, while tight end George Kittle finished with eight catches for 88 yards and a touchdown. Running back Christian McCaffrey contributed 22 carries for 73 yards, including a one-yard rushing score.
Defensively, the 49ers held the Titans to 170 total passing yards. Safety Malik Mustapha led the team with 10 tackles, linebacker Curtis Robinson added seven tackles and a pass defensed, and defensive lineman Clelin Ferrell recorded six tackles.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Monday, December 22 at 5:15 p.m. PT
Where is the game being played?
Lucas Oil Stadium in Indianapolis, Indiana
Who are the head coaches?
49ers: Kyle Shanahan
Colts: Shane Steichen
Betting Odds
As of December 17, the 49ers are favored by six points in this game, with an over/under set at 46.5 points, per BetMGM.
What channel is the game on?
Network: ESPN
Play-By-Play: Joe Buck
Color Analyst: Troy Aikman
Sideline Reporter: Lisa Salters
Sideline Reporter: Laura Rutledge
What areas will receive the broadcast?
The game will be nationally broadcast.
Where can I stream the game?
You can watch the matchup live on Watch ESPN, the ESPN app, or via NFL+.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Guy Haberman and Tim Ryan will call the game.
Colts Radio
Indianapolis fans can listen on 93.5 or 107.5 The Fan, where Matt Taylor and Rick Venturi will call the game.
National Radio
Fans can listen to the game on Westwood One Sports, where Kevin Harlan and Ross Tucker will call the game.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 45
Series Record: Colts lead series 27-18
49ers Home Record vs. Colts: Colts lead series 12-11
49ers Away Record vs. Colts: Colts lead series 15-7
First Meeting: 11/29/53, 49ers win 38-21, at Bal.*
Last Meeting: 10/24/21, Colts win 30-18, at SF
Current Streak: Lost 5
Longest 49ers Win Streak: 5 (10/26/69 – 9/10/89)
Longest Colts Win Streak: 13 (11/4/62 – 10/13/68)
Most 49ers Points: 45 (12/13/53): 49ers win 45-14, at SF
Most Colts Points: 45 (11/22/59): Colts win 45-14, at Bal.*
49ers Shutouts: None
Colts Shutouts: None
* Baltimore Colts
49ers Notes
- QB Brock Purdy passed for 295 yards and three touchdowns for a season-high 140.3 passer rating in Week 15. He also added 44 rushing yards, marking his seventh career game with a 140+ passer rating—tied for the most in NFL history through a player's first four seasons (min. 10 attempts per game), alongside Hall of Famer Kurt Warner. Purdy has thrown a touchdown pass in all six games he has played this season.
- RB Christian McCaffrey recorded a team-high 73 rushing yards and a touchdown in Week 15. He aims for his seventh consecutive game with 70+ scrimmage yards and his fifth straight game with a touchdown. McCaffrey ranks third in the NFL with 1,742 scrimmage yards and is tied for third with 14 total touchdowns this season. He is the third player in NFL history—joining Hall of Famer LaDainian Tomlinson (six seasons) and Shaun Alexander (five)—to post 1,600+ scrimmage yards and 13+ touchdowns in five career seasons. He totaled 173 scrimmage yards in his last game against Indianapolis (12/22/19 with Carolina).
- WR Jauan Jennings caught a team-high two touchdown passes last week and aims for his fourth consecutive game with a touchdown reception.
- WR Ricky Pearsall led the team with 96 receiving yards in Week 15.
- TE George Kittle finished Week 15 with eight receptions for 88 yards and a touchdown. He is tied for fourth among tight ends with six touchdown receptions this season. Since 2017, Kittle has amassed 7,864 receiving yards and 51 receiving touchdowns, making him the fifth tight end in NFL history to record 7,500+ receiving yards and 50+ receiving touchdowns in his first nine seasons.
- LB Dee Winters posted five tackles and a tackle for loss in Week 15 and aims for his fifth consecutive road game with five or more tackles.
- LB Curtis Robinson tallied seven tackles and his first pass defensed of the season in Week 15. He has recorded six or more tackles in three of his past four games.
- LB Tatum Bethune has registered 10 or more tackles in five of his past six games.
- DL Kalia Davis recorded his second pass defensed of the season in Week 15.
- DB Clelin Ferrell totaled six tackles in Week 15 and aims for his third straight game with six or more tackles. He has a tackle for loss in two of his past three games.
- S Malik Mustapha led the team with 10 tackles in Week 15 and aims for his fourth consecutive game with seven or more tackles. He has recorded a tackle for loss in two of his past three games and is seeking his third straight road game with a pass defensed.
Colts Notes
- Colts rank second in the AFC in scoring offense, averaging 28 points per game.
- QB Philip Rivers completed 18 of 27 attempts (66.7%) for 120 yards and a touchdown in Week 15, marking his first career start since 2020. He has thrown for 225+ passing yards and a touchdown in five of his past six Monday Night Football appearances. Rivers is 4-0 in four career starts against San Francisco and has recorded 250+ passing yards and two or more touchdown passes in each of those starts.
- RB Jonathan Taylor led the team with 101 scrimmage yards (87 rushing, 14 receiving) last week. He leads the NFL in rushing yards (1,443), rushing touchdowns (16), and scrimmage touchdowns (18), and ranks second in scrimmage yards (1,761) in 2025. Taylor has posted 120+ scrimmage yards in four of his past five games at Lucas Oil Stadium. He has recorded 95+ scrimmage yards and a rushing touchdown in both of his career Monday Night Football games. He totaled 110 scrimmage yards (107 rushing, three receiving) and a rushing touchdown in the last meeting.
- WR Michael Pittman Jr. has recorded six or more receptions, 60+ receiving yards, and a touchdown catch in two of his past three Monday Night Football games. He caught four passes for 105 yards and a touchdown in the last meeting.
- WR Josh Downs caught a touchdown pass in Week 15 and has a touchdown reception in two of his past three games at Lucas Oil Stadium.
- TE Tyler Warren ranks second among rookies in receptions (63) and fourth among tight ends in receiving yards (718) in 2025. He is one of three rookies—along with Emeka Egbuka and Harold Fannin—with 10 games of four or more receptions. Warren has a touchdown catch in three of his past four games at Lucas Oil Stadium.
- LB Zaire Franklin posted 10 tackles and a tackle for loss last week. He has recorded 10 or more tackles in four of his past five games and is aiming for his seventh consecutive Monday Night Football game with nine or more tackles.
- LB Germaine Pratt tallied 10 tackles and a tackle for loss in Week 15. He has a pass defensed in five of his past six games and has recorded eight or more tackles in each of his three games at Lucas Oil Stadium this season. Pratt aims for his third consecutive game against San Francisco with five or more tackles and a pass defensed.
- DE Laiatu Latu recorded three tackles for loss and a sack last week.
- S Nick Cross finished Week 15 with seven tackles and his first forced fumble of the season.
- S Cam Bynum registered eight tackles last week and has recorded a tackle for loss and a pass defensed in two of his past three games.
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