The San Francisco 49ers return to Levi's Stadium to face the Los Angeles Rams in the second of two matchups this season. This marks the 154th all-time meeting between the two teams. The 49ers lead the series 79-71-3 and aim to improve their home record to 38-36-2 against the Rams while completing a season sweep.
Previous game
The 49ers are coming off a 34-24 road victory over the New York Giants. The offense was powered by running back Christian McCaffrey, who recorded 28 carries for 106 yards and one rushing touchdown, along with five receptions for 67 yards and another score through the air. Quarterback Mac Jones was efficient, completing 19 of 24 passes for 235 yards and two touchdowns. Wide receiver Jauan Jennings added four receptions for 41 yards and a touchdown, while running back Brian Robinson Jr. contributed five carries for 53 yards and his first touchdown of the season.
Defensively, the 49ers held the Giants to just 117 rushing yards and notched two sacks on quarterback Jaxson Dart. Linebacker Tatum Bethune led the defense with a career-high 16 tackles and one pass defensed. Defensive lineman Sam Okuayinonu posted four tackles and one sack, while defensive lineman Clelin Ferrell added three tackles and a sack of his own.
Below is everything you need to know to follow the upcoming game.
When does the game start?
Sunday, November 9 at 1:25 p.m. PT
Where is the game being played?
Levi's Stadium in Santa Clara, California
Who are the head coaches?
49ers: Kyle Shanahan
Rams: Sean McVay
Betting Odds
As of November 5, the Rams are favored by 4 points in this game, with an over/under set at 49.5 points, per BetMGM.
What channel is the game on?
Network: FOX
Play-By-Play: Kevin Burkhardt
Color Analyst: Tom Brady
Sideline Reporter: Erin Andrews
Sideline Reporter: Tom Rinaldi
Viewers outside the broadcast area can watch the game via NFL Sunday Ticket on YouTube TV or YouTube Premium, but a subscription to the package is required.
What areas will receive the broadcast?
The broadcast will be viewable within the markets designated below for those without NFL Sunday Ticket.
Coverage map courtesy of 506sports.com
Where can I stream the game?
NFL Sunday Ticket subscribers can stream the game using the YouTube TV app. Those who purchased through YouTube Premium can watch via the YouTube app. Additionally, NFL+ subscribers can stream the game in its entirety once the matchup has been completed.
Bay Area fans can stream the game through the official 49ers app or at 49ers.com.
Where can I listen to the radio broadcast?
49ers Radio
Bay Area fans can listen on KGO 810 AM and The Bone 107.7 FM, where Troy Clardy and Tim Ryan will call the game.
Jesús Zárate and Carlos Yustis will call the game in Spanish. Fans can listen at 49ers.com/esp.
Rams Radio
Los Angeles area fans can listen on ESPN 710 AM, where J.B. Long and Maurice Jones-Drew will call the game.
National Radio
Fans can listen to the game via Compass Media Networks, where Josh Lewin and Kirk Morrison will provide the call.
Streaming
NFL+ subscribers can listen to the game through that service.
Game discussion
Fans can discuss the game within our Niner Talk forum.
How has this series played out historically?
Matchups: 153
Series Record: 49ers lead series 79-71-3
49ers Home Record vs. Rams: 49ers lead series 38-36-2
49ers Away Record vs. Rams: 49ers lead series 41-35-1
First Meeting: 10/1/50, Rams win 35-14, at SF
Last Meeting: 10/2/25, 49ers win 26-23 (OT), at LA
Current Streak: Won 1
Longest 49ers Win Streak: 17 (12/17/90 – 12/27/98)
Longest Rams Win Streak: 10 (11/29/70 – 9/28/75)
Most 49ers Points: 48 (12/27/87): 49ers win 48-0, at SF
Most Rams Points: 56 (11/9/58): Rams win 56-7, at LA
49ers Shutouts: 9 (Last 9/12/16), 49ers win 28-0, at SF
Rams Shutouts: None
49ers Notes
- QB Mac Jones completed 19 of 24 attempts (season-high 79.2%) for 235 yards and 2 touchdowns with 0 interceptions, earning a season-high 135.2 passer rating in Week 9. He is one of three NFC quarterbacks (along with Sam Darnold and Matthew Stafford) averaging 260+ passing yards per game (261.7) in 2025 (minimum five starts). Jones passed for 342 yards and 2 touchdowns in the Week 5 meeting.
- QB Brock Purdy has recorded 300+ passing yards and 2+ touchdown passes in three of his past four home games.
- RB Christian McCaffrey had five receptions, 173 scrimmage yards (106 rushing, 67 receiving), and 2 touchdowns (one rushing, one receiving) in Week 9—his 16th career game with both a rushing and receiving touchdown, the most in NFL history. He became the third player ever (joining Hall of Famers Marshall Faulk and Walter Payton) with 10+ games featuring 100+ rushing yards and 50+ receiving yards. McCaffrey's 33 career receiving touchdowns are the second most by a running back in the Super Bowl era. He leads the NFL with 1,222 scrimmage yards and eight games of 100+ scrimmage yards in 2025. In five career games vs. the Rams, he has 36 receptions (7.2 per game), 790 scrimmage yards (158 per game), and 7 total touchdowns (4 rushing, 2 receiving, 1 passing), topping 135 scrimmage yards in each game.
- TE George Kittle has 50+ receiving yards in five of his past six home games vs. the Rams. He needs 20 receiving yards to become the sixth tight end with 7,500+ receiving yards in his first nine career seasons.
- WR Jauan Jennings recorded his second receiving touchdown of the season last week, marking his 15th career touchdown catch. He has five touchdown receptions in six career games vs. the Rams.
- WR Kendrick Bourne had 10 receptions for 142 yards in the Week 5 meeting.
- LB Tatum Bethune tallied a career-high 16 tackles and his first career pass defended last week. Since Week 6, he leads the NFL with 50 tackles, including 10+ in each of the past four games.
- LB Dee Winters has a pass defended in two of his past three home games.
- DL Sam Okuayinonu has a sack in two of his past three games.
- DL Clelin Ferrell recorded a sack last week in his first game with San Francisco this season.
- CB Renardo Green posted his fifth career game with two passes defended last week.
- CB Upton Stout is one of three rookie defensive backs (along with Jonas Sanker and Malaki Starks) with six or more games (6) recording 5+ tackles in 2025.
- S Malik Mustapha aims for his fourth straight game with 5+ tackles.
Rams Notes
- QB Matthew Stafford passed for 281 yards and 4 touchdowns with 0 interceptions for a 140.8 passer rating in Week 9, marking his 19th career game with 4+ touchdown passes. He became the fourth player ever (joining Tom Brady, Patrick Mahomes, and Aaron Rodgers) with 20+ touchdown passes (NFL-leading 21) and 2 or fewer interceptions (2) in his first eight games of a season. Stafford has 398 career regular-season touchdown passes and can become the ninth player ever to reach 400. He has thrown 3+ touchdown passes in four of his past five games, including 389 yards and 3 touchdowns with a 111 rating in the Week 5 meeting.
- RB Kyren Williams rushed for 114 yards and recorded his 29th career rushing touchdown last week, marking his 11th career game with 100+ rushing yards. He has 50+ scrimmage yards in 36 straight games, the longest active streak in the NFL. Williams has 459 scrimmage yards (114.8 per game) and 7 touchdowns (4 receiving, 3 rushing) in four career games vs. San Francisco, including 2+ touchdowns in three of those four games. He aims for his fifth consecutive game vs. San Francisco with 100+ scrimmage yards.
- WR Davante Adams recorded his 26th career game with 2 receiving touchdowns last week, the sixth-most such games in the Super Bowl era. He leads the NFL with 8 receiving touchdowns in 2025 and became the fifth wide receiver in the Super Bowl era with 8+ receiving touchdowns in six straight seasons. Adams has 111 career receiving touchdowns, tied for eighth-most in NFL history. He has 721 receiving yards (120.2 per game) and 7 receiving touchdowns in six career regular-season games vs. San Francisco.
- WR Puka Nacua had 7 receptions for 95 yards and his 12th career receiving touchdown last week. He has recorded 5+ catches in 14 of his past 15 games. Nacua has 85+ receiving yards in six of his seven games in 2025 and in three of his four career games vs. San Francisco.
- LB Byron Young has recorded 0.5+ sacks in four of his five career games vs. San Francisco. He ranks third in the NFL with a career-high 9 sacks in 2025.
- LB Nate Landman recorded his eighth career forced fumble last week. He had 14 tackles, 3 passes defended, and a tackle for loss in the Week 5 meeting. Landman aims for his sixth consecutive game with 5+ tackles.
- DE Braden Fiske recorded his first sack of the season last week.
- CB Emmanuel Forbes tied his career high with 3 passes defended and recorded his first interception of the season in Week 9.
- S Quentin Lake has a career-high 10 passes defended in 2025. He had 11 tackles in the Week 5 meeting.