The San Francisco 49ers dropped to 4-2 on the season after a 30-19 Week 6 loss to the Tampa Bay Buccaneers at Raymond James Stadium in Tampa, Florida.
Below are several statistics and notes from Sunday's game, which were provided by the 49ers Communications staff.
QB Mac Jones
- QB Mac Jones completed 27 of his 39 passing atts. for 347 yds. on the day.
- Jones' 347 passing yds. marked his 7th career game with 300-or-more passing yds. With 342 passing yds. last week at LAR (10/2/25) and 347 passing yds. on the day, Jones has thrown for 300 or more passing yds. in consecutive games for the first time in his career.
- Through his first 4 starts with the 49ers, Jones has thrown for 1,252 passing yds., which surpasses former QB Jimmy Garoppolo (1,250 passing yds. in first 4 starts) for the most by a 49ers QB through their first 4 starts with the team.
RB Christian McCaffrey
- RB Christian McCaffrey registered 17 carries for 54 yds. and 1 TD on the ground to go along with 7 recepts. for 57 yds. through the air.
- McCaffrey's rushing TD marked his first of the season and the 53rd of his career.
- McCaffrey's 54 rec. yds. on the day make him the first RB in NFL history to record 50-or-more rec. yds. in each of his team's first six games of a season. It also marks his 46th career game with 50-or-more rec. yds., which is tied for the 4th-most games with at least 50 rec. yds. by a RB in the Super Bowl Era.
MOST GAMES WITH 50-OR-MORE REC. YDS. BY A RB, SUPER BOWL ERA
| Rank | Player | Games |
| 1. | RB Larry Centers, Pho./Arz./Was./Buf./NE | 55 |
| 2. | RB Marshall Faulk, Ind./StL | 50 |
| 3. | RB Ronnie Harmon, Buf./SD/Hou. | 47 |
| 4t. | RB Christian McCaffrey, Car./SF | 46 |
| RB Keith Byars, Phi./Mia./NE/NYJ | 46 |
- With 7 recepts. on the day, McCaffrey has now recorded 46 recepts. this season, joining former Chicago Bears RB Matt Forte (46 recepts. in 2014) and New Orleans Saints RB Alvin Kamara (46 recepts. in 2020) for the most recepts. by a RB in his team's first 6 games of a season in NFL history.
- With 9 recepts. Week 1 at Sea. (9/7/25), 6 recepts. at NO (9/14/25), 10 recepts. vs. Arz. (9/21/25), 6 recepts. vs. Jax. (9/28/25), 8 recepts. at LAR (10/2/25) and 7 recepts. on the day, McCaffrey joins former Chicago Bears RB Matt Forte (2014), former New Orleans Saints RB Darren Sproles (2011), former Kansas City Chiefs RB Priest Holmes (2002) and former Arizona Cardinals RB Larry Centers (1995) as the only RBs in NFL history to record 5-or-more recepts. in each of his team's first 6 games of a season.
- With 111 yds. from scrimmage, McCaffrey registered his 63rd career game with 100-or-more yds. from scrimmage and his 26th such game as a member of the 49ers.
- McCaffrey's 63 games with 100-or-more yds. from scrimmage are the most among active NFL RBs.
MOST GAMES WITH 100-OR-MORE YDS. FROM SCRIMMAGE, ACTIVE NFL RBs
| Rank | Player | Games |
| 1. | RB Christian McCaffrey, Car./SF | 63 |
| 2. | RB Derrick Henry, Ten./Bal. | 61 |
| 3. | RB Alvin Kamara, NO | 58 |
| 4. | RB Saquon Barkley, NYG/Phi. | 48 |
| 5. | RB Josh Jacobs, Oak./LV/GB | 40 |
- With 142 yds. from scrimmage Week 1 at Sea. (9/7/25), 107 yds. from scrimmage Week 2 at NO (9/14/25), 140 yds. from scrimmage Week 3 vs. Arz. (9/21/25), 141 yds. from scrimmage Week 4 vs. Jax. (9/28/25), 139 yds. from scrimmage Week 5 at LAR (10/2/25) and 111 yds. from scrimmage on the day, McCaffrey has now registered the 2nd-most consecutive games with 100-or-more yds. from scrimmage to begin a season in franchise history.
MOST CONSECUTIVE GAMES WITH 100-OR-MORE YDS. FROM SCRIMMAGE TO BEGIN A SEASON, FRANCHISE HISTORY
| Rank | Player | Games | Season |
| 1. | RB Roger Craig | 7 | 1988 |
| 2. | RB Christian McCaffrey | 6 | 2025 |
| 3. | RB Paul Hofer | 5 | 1980 |
| 4. | RB Christian McCaffrey | 4 | 2023 |
| 5t. | WR Dwight Clark | 3 | 1982 |
| RB Garrison Hearst | 3 | 1998 | |
| RB Raheem Mostert | 3 | 2020 | |
| WR Jerry Rice | 3 | 1989 |
- McCaffrey is also the first RB to begin a season with 100-or-more yds. from scrimmage in each of his team's first 6 games of a season since RB Saquon Barkley did so as a member of the New York Giants in 2018 [128 yds. from scrimmage vs. Jax. (9/9/18); 108 yds. from scrimmage at Dal. (9/16/18); 117 yds. from scrimmage at Hou. (9/23/18); 100 yds. from scrimmage vs. NO (9/30/18); 129 yds. from scrimmage at Car. (10/7/18); 229 yds. from scrimmage vs. Phi. (10/11/18)].
- With 54 rushing yds. and 57 rec. yds., McCaffrey registered his 35th career game with 50-or-more rushing yds. and 50-or-more rec. yds., which is the 2nd-most such games in NFL history (RB Marshall Faulk, Ind./StL – 41 games).
MOST GAMES WITH 50-OR-MORE RUSHING YDS. AND 50-OR-MORE REC. YDS., NFL HISTORY
| Rank | Player | Games |
| 1. | RB Marshall Faulk, Ind./StL | 41 |
| 2. | RB Christian McCaffrey, Car./SF | 35 |
| 3. | RB Alvin Kamara, NO | 24 |
| 4t. | RB Tiki Barber, NYG | 23 |
| RB LaDanian Tomlinson, SD/NYJ | 23 |
- Of those 35 games, McCaffrey has recorded 11 as a member of the 49ers. His 11 games with 50-or-more rushing yds. and 50-or-more rec. yds. are the 3rd-most in franchise history.
MOST GAMES WITH 50-OR-MORE RUSH YDS. AND 50-OR-MORE REC. YDS., FRANCHISE HISTORY
| Rank | Player | Games |
| 1. | RB Roger Craig | 17 |
| 2. | RB Frank Gore | 14 |
| 3. | RB Christian McCaffrey | 11 |
| 4. | RB Ricky Watters | 8 |
| 5. | RB Charlie Garner | 7 |
- McCaffrey has registered 50-or-more rushing yds. and 50-or-more rec. yds. in five of the team's first six games this season, making him the 2nd player in NFL history to accomplish the feat (RB Marshall Faulk, StL – 2000).
WR Kendrick Bourne
- WR Kendrick Bourne registered 5 recepts. for a team-high 142 yds. on the day.
- Bourne's 142 rec. yds. mark his 3rd career game with 100-or-more rec. yds. With 142 rec. yds. last week at LAR (10/2/25) and 142 rec. yds. on the day, Bourne has registered 100 or more rec. yds. in consecutive games for the first time in his career.
- Bourne also became the first 49ers WR to register consecutive games with 100-or-more rec. yds. since former WR Deebo Samuel Sr. did so in the 2023 season [116 rec. yds. at Phi. (12/3/23); 149 rec. yds. vs. Sea. (12/10/23)].
TE Jake Tonges
- TE Jake Tonges registered 6 recepts. for 58 yds., tying his career high in rec. yds. [58 rec. yds. vs. Jax. (9/28/25)].
DL Mykel Williams
- DL Mykel Williams registered 3 tackles and 1.0 sacks of Buccaneers QB Baker Mayfield. His sacks of Mayfield marked the first of his career.
LB Tatum Bethune
- LB Tatum Bethune registered a career-high 10 tackles on the day.
K Eddy Piñeiro
- K Eddy Piñeiro converted on each of his FGAs (52, 54, 42 & 29) and his lone PAT.
- With 4 FGM on the day, Piñeiro has converted on each of his first 15 FGAs since joining the team in Week 2. His 15-consecutive FGM are tied for the most by any kicker to begin their first season with the 49ers (K Robbie Gould – 15-consecutive FGM in 2017).
- With 4 FGM last week at LAR (10/2/25) and 4 FGM on the evening, Piñeiro became the first 49ers kicker to register 4-or-more FGM in consecutive games since former K Robbie Gould in 2017 [5 FGM at Chi. (12/3/17); 4 FGM at Hou. (12/10/17); 6 FGM vs. Ten. (12/17/17)].