The San Francisco 49ers are preparing for their Week 2 contest against the New Orleans Saints on Sunday at the Caesars Superdome in New Orleans, Louisiana. Both teams have released their official injury reports, which are provided below.
San Francisco 49ers
Out
QB Brock Purdy (left shoulder, toe)
Questionable
WR Jauan Jennings (shoulder), T Trent Williams (knee)
New Orleans Saints
Out
S Julian Blackmon (shoulder), G Trevor Penning (toe), DE Chase Young (calf)
Questionable
T Taliese Fuaga (knee)
Injury Notes
As expected, quarterback Brock Purdy (left shoulder, toe) did not practice and will miss Sunday's game. Mac Jones is set to make his first start with the 49ers. The team will elevate Adrian Martinez from the practice squad to serve as Jones' backup.
Jones could face a challenging debut as the team's starting left tackle, Trent Williams (knee), is uncertain for Sunday. He was limited in practice after not participating earlier in the week.
On a positive note, wide receiver Jauan Jennings (shoulder) returned to practice Friday after not participating earlier in the week. Williams and Jennings are "questionable" to play.
Air Jauan 🌪 pic.twitter.com/cQcsPMmx0R
— 49ers on NBCS (@NBCS49ers) September 12, 2025
Below are Friday's practice participation reports for both the 49ers and Saints, which were provided by the 49ers Communications staff.
San Francisco 49ers Friday Practice
Did Not Participate In Practice
QB Brock Purdy (left shoulder, toe)
Limited Participation in Practice
WR Jauan Jennings (shoulder), T Trent Williams (knee)
Full Participation in Practice
G Ben Bartch (knee, elbow), DE Nick Bosa (not injury related - resting player), LB Luke Gifford (knee), RB Jordan James (finger), QB Mac Jones (knee), RB Christian McCaffrey (calf), G Dominick Puni (knee), WR Jordan Watkins (ankle)
New Orleans Saints Friday Practice
Did Not Participate In Practice
S Julian Blackmon (shoulder), G Trevor Penning (toe), DE Chase Young (calf)
Limited Participation in Practice
T Taliese Fuaga (knee)
Full Participation in Practice
S Jordan Howden (oblique), RB Velus Jones (knee), LS Zach Wood (elbow)