The San Francisco 49ers kicked off their 2025 preseason at Levi's Stadium, hosting the Denver Broncos in their opener. Most starters are sidelined during Saturday's matchup, which was expected.
Below are the latest in-game injury updates for the 49ers. This article will be updated in real-time as new information becomes available.
RB Ameer Abdullah (ribs, questionable)
Ameer Abdullah fumbled the football in the third quarter and immediately grabbed his side in pain. He entered the medical tent to be examined. The 49ers announced that Abdullah is questionable to return due to a rib injury.
#49ers RB Ameer Abdullah walks off the field after getting checked in the blue medical tent and is questionable to return with a rib injury. pic.twitter.com/a1sTKDOttC
— OurSF49ers (@OurSf49ers) August 10, 2025
S Marques Sigle (knee, questionable)
Marques Sigle headed to the medical tent in the second quarter. The 49ers later announced he is questionable to return to the game.
LB Tatum Bethune (ankle, questionable)
Tatum Bethune was shaken up in the second quarter after making a tackle on Broncos running back Tyler Badie. He walked to the sideline, where medical staff evaluated him. The 49ers announced he was questionable to return, but he reentered the game shortly afterward.