The San Francisco 49ers are gearing up to host the Arizona Cardinals at Levi's Stadium in Santa Clara, California, on Sunday, October 6, at 1:05 p.m. PT. The 49ers are favored by seven points in this NFC West matchup, and many are expecting a strong performance from the home team.
Each week, 49ers Webzone staff members participate in the NFL Pick 'em contest, predicting the winners of every NFL game. For Week 5, three of the four participating staff members picked the 49ers to emerge victorious over the Cardinals.
Most One-Sided Matchup: Cardinals at 49ers
Additionally, 49ers fans are showing overwhelming confidence in their team. According to the NFL Pick 'em contest results, 98% of fans predict a 49ers win in Week 5, making this the most one-sided matchup in terms of predictions.
Most Competitive Matchup: Colts at Jaguars
While the 49ers are heavily favored to defeat the Cardinals, the closest contest in terms of predictions is Sunday's AFC South battle between the Indianapolis Colts and the Jacksonville Jaguars. In that matchup, 52% of fans are siding with the Jaguars for the win.
Week 5 NFL Matchups
Below is a breakdown of all 13 matchups for the upcoming slate of NFL games.
| Picks | Away | Home | Picks |
|---|---|---|---|
|
21%
|
Jets
|
Vikings
|
79%
|
|
15%
|
Panthers
|
Bears
|
85%
|
|
80%
|
Ravens
|
Bengals
|
20%
|
|
43%
|
Dolphins
|
Patriots
|
57%
|
|
15%
|
Browns
|
Commanders
|
85%
|
|
48%
|
Colts
|
Jaguars
|
52%
|
|
65%
|
Bills
|
Texans
|
35%
|
|
39%
|
Raiders
|
Broncos
|
61%
|
|
2%
|
Cardinals
|
49ers
|
98%
|
|
78%
|
Packers
|
Rams
|
22%
|
|
3%
|
Giants
|
Seahawks
|
97%
|
|
55%
|
Cowboys
|
Steelers
|
45%
|
|
22%
|
Saints
|
Chiefs
|
78%
|