49ers vs. Patriots Injury Report: George Kittle returns to practice; Brock Purdy full-go

The San Francisco 49ers are preparing for their Week 4 contest against the New England Patriots on Sunday at Levi's Stadium in Santa Clara, California.

The 49ers received difficult injury news this week, as defensive tackle Javon Hargrave is expected to miss the remainder of the season after suffering a partially torn triceps in Week 3's loss to the Los Angeles Rams.

On a more positive note, tight end George Kittle returned to practice after missing the Rams game due to a hamstring injury, though he was limited during Wednesday's session.

"George is a captain and one of the most important players on the team in terms of production, and just a morale boost from his positivity," defensive end Nick Bosa said on Wednesday. "And, yeah, just having a guy who's been around for a while, has been through the ups and downs of the [Kyle] Shanahan regime. So, yeah, we're excited [to have him back]."

There were concerns about Brock Purdy after he reported to the team on Monday with back soreness. However, an MRI revealed no significant issues, and Purdy was a full participant during Wednesday's practice.

RELATED Brock Purdy cleared for full practice on Wednesday

Wide receiver Deebo Samuel continues to be sidelined. He missed the game against the Rams and is expected to sit out Sunday's matchup against the Patriots due to a calf strain. Additionally, linebacker Dee Winters re-aggravated an ankle injury on Sunday and did not participate in practice.

Tackle Trent Williams was absent from practice due to an illness.

Below are Wednesday's practice participation reports for both the 49ers and Patriots, which were provided by the 49ers Communications staff.

San Francisco 49ers Wednesday Practice

Did Not Participate In Practice
DT Javon Hargrave (triceps), WR Deebo Samuel (calf), T Trent Williams (illness), LB Dee Winters (ankle)

Limited Participation in Practice
TE George Kittle (hamstring)

Full Participation in Practice
QB Brock Purdy (back)

New England Patriots Wednesday Practice

Did Not Participate In Practice
CB Alex Austin (ankle), LB Anfernee Jennings (shoulder), G Michael Jordan (ankle), T Vederian Lowe (knee)

Limited Participation in Practice
C David Andrews (not injury related - resting player), CB Christian Gonzalez (shoulder), TE Hunter Henry (ankle), CB Jonathan Jones (shoulder), G Sidy Sow (ankle), T Caedan Wallace (knee)

Full Participation in Practice
G Michael Onwenu (wrist), S Jabrill Peppers (ankle)