The San Francisco 49ers are hosting the Los Angeles Rams in a Week 18 contest at Levi's Stadium.
With the top seed in the playoffs locked up, the 49ers rested several starters, including quarterback Brock Purdy. Defensive tackle Arik Armstead, safety Ji'Ayir Brown, safety Tashaun Gipson, running back Christian McCaffrey, cornerback Ambry Thomas, and wide receiver Jauan Jennings were also among the 49ers' inactive players, all due to injuries.
Tight end George Kittle (back spasms) and linebacker Dre Greenlaw (tendonitis) were listed as "active" but did not suit up for the game.
Below are the 49ers-related in-game injury updates.
DE Clelin Ferrell (knee, out)
Early in the game, the 49ers declared Clelin Ferrell "out" for the remainder of the game due to a knee injury. The severity of the injury is unknown. It may simply be a precaution, as this game holds little meaning for the 49ers. Ferrell has started all 17 games this season.
This article will be updated as the game progresses.