The San Francisco 49ers are set to host the New York Giants at Levi's Stadium in Santa Clara, California, on Thursday, September 21, at 5:15 p.m. PT. Each week, the 49ers Webzone staff predicts the winner within its annual NFL Pick 'em contest. That includes writers and forum moderators.
This week, all seven participating staff members selected the 49ers to beat the Giants. San Francisco is currently a 10.5-point favorite.
As for all the fans taking part in our NFL Pick 'em contest, 99 percent have the 49ers winning the game, as of this post.
Of all the Week 3 game predictions, the most lopsided results come from three matchups—Giants at 49ers, Bears at Chiefs, and Cowboys at Cardinals. Ninety-nine percent of fans pick the 49ers, Chiefs, and Cowboys to win those games.
When it comes to the predictions, the closest matchup is between the Los Angeles Chargers and the Minnesota Vikings on Sunday, with 53 percent selecting the Chargers to win the game.
Below is a breakdown of all 16 matchups for the upcoming slate of NFL games.
| Picks | Away | Home | Picks |
|---|---|---|---|
|
1%
|
Giants
|
49ers
|
99%
|
|
42%
|
Titans
|
Browns
|
58%
|
|
8%
|
Falcons
|
Lions
|
92%
|
|
35%
|
Saints
|
Packers
|
65%
|
|
3%
|
Broncos
|
Dolphins
|
97%
|
|
53%
|
Chargers
|
Vikings
|
47%
|
|
68%
|
Patriots
|
Jets
|
32%
|
|
94%
|
Bills
|
Commanders
|
6%
|
|
3%
|
Texans
|
Jaguars
|
97%
|
|
3%
|
Colts
|
Ravens
|
97%
|
|
4%
|
Panthers
|
Seahawks
|
96%
|
|
1%
|
Bears
|
Chiefs
|
99%
|
|
99%
|
Cowboys
|
Cardinals
|
1%
|
|
40%
|
Steelers
|
Raiders
|
60%
|
|
94%
|
Eagles
|
Buccaneers
|
6%
|
|
35%
|
Rams
|
Bengals
|
65%
|