The Los Angeles Rams are set to host the San Francisco 49ers at SoFi Stadium in Inglewood, California, on Sunday, September 17, at 1:05 p.m. PT. Each week, the 49ers Webzone staff predicts the winner within its annual NFL Pick 'em contest. That includes writers and forum moderators.
This week, all seven participating staff members selected the 49ers to beat the Rams. San Francisco is currently a 7.5-point favorite.
As for all the fans taking part in our NFL Pick 'em contest, 97 percent have the 49ers winning the game, as of this post.
Of all the Week 2 game predictions, the most lopsided result comes from the 49ers-Rams matchup.
When it comes to the predictions, the closest matchup is between the Indianapolis Colts and the Houston Texans on Sunday, with fans evenly split on which team will win.
Below is a breakdown of all 15 matchups for the upcoming slate of NFL games.
| Picks | Away | Home | Picks |
|---|---|---|---|
|
64%
|
Packers
|
Falcons
|
36%
|
|
8%
|
Raiders
|
Bills
|
92%
|
|
32%
|
Ravens
|
Bengals
|
68%
|
|
10%
|
Seahawks
|
Lions
|
90%
|
|
87%
|
Chargers
|
Titans
|
13%
|
|
23%
|
Bears
|
Buccaneers
|
77%
|
|
76%
|
Chiefs
|
Jaguars
|
24%
|
|
50%
|
Colts
|
Texans
|
50%
|
|
97%
|
49ers
|
Rams
|
3%
|
|
87%
|
Giants
|
Cardinals
|
13%
|
|
9%
|
Jets
|
Cowboys
|
91%
|
|
26%
|
Commanders
|
Broncos
|
74%
|
|
86%
|
Dolphins
|
Patriots
|
14%
|
|
87%
|
Saints
|
Panthers
|
13%
|
|
59%
|
Browns
|
Steelers
|
41%
|