San Francisco 49ers quarterback Brock Purdy became the team's starter in Week 14 of last season and has not looked back since. He led the 49ers to victory in each of their final five regular-season games, recording at least two touchdown passes and a passer rating of 95 or higher in each contest. Purdy became the third rookie quarterback ever to win each of his first five career starts.
With at least two touchdown passes and a victory at Pittsburgh on Kickoff Weekend (10:00 AM PT, FOX), Purdy will become the first quarterback in NFL history to win each of his first six career regular-season starts and throw at least two touchdown passes in each start.
He can also become the first quarterback in NFL history with a passer rating of 95 or higher in each of his first six career regular-season starts.
Brock Purdy's 2022 regular-season starts:
| Week | Opponent | Result | Pass Yds | Pass TDs | Rating |
| Week 14 | vs. Tampa Bay | W 35-7 | 185 | 2 | 134.0 |
| Week 15 | at Seattle | W 21-13 | 217 | 2 | 117.0 |
| Week 16 | vs. Washington | W 37-20 | 234 | 2 | 114.6 |
| Week 17 | at Las Vegas | W 37-34 (OT) | 284 | 2 | 95.4 |
| Week 18 | vs. Arizona | W 38-13 | 178 | 3 | 141.3 |
Information provided by NFL Communications.