Below are several statistics and notes from Sunday's game, which were provided by the 49ers Communications staff.
With the Win…
- The 49ers improved to 8-8 overall against the Chargers, including a 4-3 mark at home.
- The Niners defeated the Chargers for the first time since 2000 [W, 45-17 at SD (12/3/00)].
- San Francisco has won back-to-back games for the first time this season.
- The 49ers are now 3-1 at home in 2022.
- Head coach Kyle Shanahan improves to 1-1 against the Chargers as the head coach of the 49ers.
Offense
- The 49ers offense finished with 41 rushing atts. for 157 yds. and 2 TDs on the night. San Francisco improved to 8-0 in the regular season, and 2-0 in 2022, when registering 40-or-more rushing atts. in a single game under head coach Kyle Shanahan.
49ERS GAMES WITH 40-OR-MORE RUSHING ATTS., 2017-22
| Date | Opp. | Rush Atts. | Rush Yds. | Result |
| 9/15/19 | at Cin. | 42 | 259 | W, 41-17 |
| 9/22/19 | vs. Pit. | 40 | 168 | W, 24-20 |
| 10/7/19 | vs. Cle. | 40 | 275 | W, 31-3 |
| 10/13/19 | at LAR | 41 | 99 | W, 20-7 |
| 11/15/21 | vs. LAR | 44 | 156 | W, 31-10 |
| 11/21/21 | at Jax. | 42 | 171 | W, 30-10 |
| 9/18/22 | vs. Sea. | 45 | 189 | W, 27-7 |
| 11/13/22 | vs. LAC | 41 | 157 | W, 22-16 |
Jimmy Garoppolo
- QB Jimmy Garoppolo completed 19 of 28 atts. for 240 yds. to go along with 5 carries for 3 yds. and 1 TD.
- The rushing TD marked Garoppolo's 2nd of the season and 7th of his career.
Christian McCaffrey
- RB Christian McCaffrey registered 14 carries for 38 yds. and 1 TD to go along with 4 recepts. for 39 yds.
- McCaffrey has registered 1-or-more rushing TDs in back-to-back games for the 12th time in his career and the first time since Weeks 1-2 of the 2020 season.
Deebo Samuel
- WR Deebo Samuel tallied 2 recepts. for 24 yds. to go along with 4 carries for 27 yds.
- With 2 recepts., Samuel has now registered 201 career recepts. In just 46 career games, he has registered 200 career recepts. in the 3rd-fewest amount of games by a member of the 49ers dating back to 1970 [TE George Kittle – 43 games & WR Jerry Rice – 44 games].
FASTEST MEMBER OF THE 49ERS TO 200 RECEPTS., SINCE 1970
| Player | Games |
| TE George Kittle | 43 |
| WR Jerry Rice | 44 |
| WR Deebo Samuel | 46 |
| WR Michael Crabtree | 48 |
| WR Dwight Clark | 50 |
- With 24 yds., Samuel has now registered 3,009 career rec. yds. In just 46 career games, he has registered 3,000 career rec. yds. in the 3rd-fewest amount of games by a member of the 49ers dating back to 1970 [WR Jerry Rice – 38 games & WR Vic Washington – 44 games].
FASTEST MEMBER OF THE 49ERS TO 3,000 REC. YDS., SINCE 1970
| Player | Games |
| WR Jerry Rice | 38 |
| WR Vic Washington | 44 |
| WR Deebo Samuel | 46 |
| TE George Kittle | 47 |
| WR Dwight Clark | 55 |
| WR Michael Crabtree | 55 |
Talanoa Hufanga
- S Talanoa Hufanga finished with 2 tackles and registered 1 INT of Chargers QB Justin Herbert. He now has 4 INTs on the season and his career.
- Hufanga's 4 INTs this season are the most by a member of the 49ers in a single season since CB Perrish Cox registered 5 INTs in 2014.
Nick Bosa
- DL Nick Bosa brought down Herbert for a 1-yd. sack, giving him 9.5 on the season and 34.0 in his career.
- Bosa has now registered 1.0-or-more sacks in 7 of his 8 games played this season.
Charles Omenihu
- DL Charles Omenihu brought down Herbert for a 7-yd. sack and a FF. The sack marked his 4th of the season and 11th of his career and the FF marked the 3rd of his career and first since 2019 as a member of the Houston Texans [at KC (10/23/19)].
- It also marked Omenihu's 3rd career game with 1.0-or-more sacks and 1-or-more FFs.
Jordan Willis
- DL Jordan Willis registered 4 tackles and 1.0 sack of Chargers QB Chase Daniel. The sack was Willis' first of the season and gave him 9.5 in his career.
