Head coach Kyle Shanahan spoke with reporters following the San Francisco 49ers' 33-6 victory over the New England Patriots and provided several injury updates.
- Wide receiver Deebo Samuel suffered a hamstring injury.
- Running back Jeff Wilson Jr. suffered an ankle injury.
- Wide receiver Richie James suffered an ankle injury.
"Jeff, we're worried it's a high-ankle sprain," Shanahan said. "That's kind of what it looked like a little bit. I know he's hurting right now. Hopefully, we'll get better news on that tomorrow, but it's not sounding great right now."
Jeremy Fowler of ESPN provided the following update on Wilson.
X-rays came back negative, I'm told, so no significant damage for San Fran's leading rusher vs Patriots RT @AdamSchefter: 49ers think RB Jeff Wilson suffered a high ankle sprain.
— Jeremy Fowler (@JFowlerESPN) October 25, 2020
"Deebo, with a hamstring, you never know," Shanahan continued. "I know it pulled on him on that run, which usually is some time. Hopefully, the severity won't be too bad, and he won't miss too much time.
"Richie, I'm not sure what type of ankle injury it was. They didn't give me any information on that. I know he wasn't able to go back in."
None of the three players returned to the game.
Wilson, 24, sustained his injury in the third quarter while rushing for his third touchdown of the game. He was able to walk gingerly under his own power off the field, was carted to the locker room, and later ruled "out."
Wilson finished the game with 112 rushing yards on 17 carries and two catches for eight yards.
Samuel, 24, exited the game with the 49ers up by 24 points in the fourth quarter. The injury came after the receiver took a one-yard toss from quarterback Jimmy Garoppolo and proceeded to the 14-yard line, setting up a 32-yard field goal and giving San Francisco a 33-6 lead. He too was eventually ruled "out."
Samuel finished the game with five catches for 65 yards and three carries for seven yards.