The San Francisco 49ers were initially expected to have running back Matt Breida (ankle) available against the Baltimore Ravens today. Then it turned out he will not play, according to Ian Rapoport of NFL Network. The running back reaggravated an ankle injury during the team's Week 10 loss to the Seattle Seahawks.

The 49ers will likely be without another key offensive component at M&T Bank Stadium. Starting left tackle Joe Staley, who suffered a fractured finger during Week 10 against the Seattle Seahawks, is not expected to play, according to Matt Maiocco of NBC Sports Bay Area. He was listed on Friday as "questionable" against the Ravens.

Today will be Staley's third consecutive missed game since returning for one game against the Seahawks. He had suffered a fractured fibula during Week 2 against the Cincinnati Bengals and missed the next six games. Staley's total of missed games this season will increase to nine today.

In addition to the team's two players listed as "questionable," Staley and Breida, the 49ers will also be without defensive end Dee Ford (quadricep, hamstring) and wide receiver Dante Pettis (knee), who were ruled "out" on Friday.

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