San Francisco 49ers head coach Kyle Shanahan told reporters on Tuesday that running back Matt Breida is day-to-day after he aggravated his ankle again on Monday night against the Seattle Seahawks.

"Day-to-day," the coach said, not "week-to-week," which would indicate there is a chance Breida is available on Sunday against the Arizona Cardinals.

Ian Rapoport of NFL Network, however, reported this morning that Breida could miss a week or two after aggravating the ankle sprain, and is seeking a second opinion. It's an injury that put the running back's status into question during the 49ers' and Cardinals' first meeting in Week 9.

Breida, the 49ers' leading rusher, has 542 yards on 109 carries with a rushing touchdown through nine games and five starts this season. He also has 16 receptions for 110 yards and a receiving touchdown.

Shanahan provided injury updates on several players, including Joe Staley, Emmanuel Sanders, George Kittle, and Robbie Gould, during a Tuesday conference call.

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The 49ers' first practice of the week is scheduled for today at 2:10 p.m. PT. That's when we will learn if Breida is healthy enough to at least get a little bit of work in as the team prepares for the Cardinals.