San Francisco 49ers right tackle Trent Brown did not practice on Friday after missing the team's previous two this week. Head coach Kyle Shanahan announced on Friday that Brown would be placed on injured reserve due to a shoulder injury, which ends his season.

Guard Zane Beadles will start in his place for the second-straight week. This past Sunday against the Houston Texans, Beadles allowed a sack, and six quarterback hurries in place of Brown, according to Pro Football Focus.

Cornerbacks Greg Mabin (calf) and Ahkello Witherspoon (knee) are questionable for Sunday.

Below are the official injury reports for the 49ers and Titans. Also included are Friday's practice participation reports, which were provided by the 49ers Communications team.

San Francisco 49ers


Out
T Trenton Brown (shoulder)

Questionable
CB Greg Mabin (calf), CB Ahkello Witherspoon (knee)

Tennessee Titans


Out
LB Derrick Morgan (knee)

Questionable
S Johnathan Cyprien (back), TE Phillip Supernaw (ankle)

San Francisco 49ers Friday Practice


Did Not Participate In Practice
T Trenton Brown (shoulder)

Limited Participation in Practice
S Adrian Colbert (thumb, thigh), CB Greg Mabin (calf), WR Louis Murphy (illness), LB Mark Nzeocha (hamstring), CB Ahkello Witherspoon (knee)

Tennessee Titans Friday Practice


Did Not Participate In Practice
S Johnathan Cyprien (back), LB Derrick Morgan (knee)

Limited Participation in Practice
TE Phillip Supernaw (ankle)

Full Participation in Practice
T Taylor Lewan (back), QB Marcus Mariota (knee)