Below is a list of the 49ers' 2017 opponents. Dates and times will be released in April prior to the NFL Draft.
| 49ers 2017 Opponents | |
| Home | Away |
| Cowboys | Eagles |
| Giants | Redskins |
| Jaguars | Texans |
| Titans | Colts |
| Panthers | Bears |
| Cardinals | Cardinals |
| Rams | Rams |
| Seahawks | Seahawks |
Fast Facts
Air mileage: 23,758 miles
The 49ers will play the Bears for the fourth straight year and their third straight in Chicago.
The 49ers will play the Dallas Cowboys for their second straight year with both games being at home.