49ers All-Time Scores
Regular Season vs Buffalo Bills
Games: 27
Record: 6-8
Points for: 606 (22.4 per game)
Points against: 606 (22.4 per game)
Italics indicates an overtime game
| 1972 Season | |||
|---|---|---|---|
| Sun, Sep 24 | at Buffalo Bills | L | 20-27 |
| 1980 Season | |||
|---|---|---|---|
| Sun, Dec 21 | Buffalo Bills | L | 13-18 |
| 1983 Season | |||
|---|---|---|---|
| Sun, Dec 11 | at Buffalo Bills | W | 23-10 |
| 1989 Season | |||
|---|---|---|---|
| Sun, Dec 17 | Buffalo Bills | W | 21-10 |
| 1992 Season | |||
|---|---|---|---|
| Sun, Sep 13 | Buffalo Bills | L | 31-34 |
| 1995 Season | |||
|---|---|---|---|
| Sun, Dec 3 | Buffalo Bills | W | 27-17 |
| 1998 Season | |||
|---|---|---|---|
| Sun, Oct 4 | at Buffalo Bills | L | 21-26 |
| 2001 Season | |||
|---|---|---|---|
| Sun, Dec 2 | Buffalo Bills | W | 35-0 |
| 2004 Season | |||
|---|---|---|---|
| Sun, Dec 26 | Buffalo Bills | L | 7-41 |
| 2008 Season | |||
|---|---|---|---|
| Sun, Nov 30 | at Buffalo Bills | W | 10-3 |
| 2012 Season | |||
|---|---|---|---|
| Sun, Oct 7 | Buffalo Bills | W | 45-3 |
| 2016 Season | |||
|---|---|---|---|
| Sun, Oct 16 | at Buffalo Bills | L | 16-45 |
| 2020 Season | |||
|---|---|---|---|
| Mon, Dec 7 | Buffalo Bills | L | 24-34 |
| 2024 Season | |||
|---|---|---|---|
| Sun, Dec 1 | at Buffalo Bills | L | 10-35 |