According to Matt Barrows of the Sacramento Bee, the 49ers' medical staff determined that Hyde would benefit from not playing against the Rams. Reggie Bush or Mike Davis will start Sunday.
WR Anquan Boldin is listed as questionable with a hamstring injury. However, when asked if he'd play on Sunday morning, he said, "Oh, there ain't no doubt in my mind." Boldin missed practice on Friday.
The 49ers kick off against the Rams on Sunday at 10 AM.
Below are the injury reports for both teams that were released on Friday.
San Francisco 49ers
Out: RB Carlos Hyde (foot)
Questionable: WR Anquan Boldin (hamstring)
Probable: G Alex Boone (shoulder, knee), LB Navorro Bowman (shoulder), LB Ahmad Brooks (shoulder), DT Tony Jerod-Eddie (not injury related), QB Colin Kaepernick (right hand), T Erik Pears (back), S Eric Reid (chest), T Joe Staley (shoulder)
St. Louis Rams
Out: DE Chris Long (knee)
Questionable: DE William Hayes (thigh), RB Tre Mason (ankle), S T.J. McDonald (shoulder), DE Robert Quinn (knee)
Probable: DT Nick Fairley (illness), TE Lance Kendricks (thumb), LB James Laurinaitis (elbow)