The 49ers are coming off of a 27-20 win over the New York Giants while the Cardinals are coming off of a 21-17 win over the Philadelphia Eagles.
The game kicks off at 1:05 PM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on FOX.
In the 49erswebzone.com Pick 'Em Contest, 98% of 49ers fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 93% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.
More San Francisco 49ers News
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49ers in Melbourne: Rams' plan to avoid San Francisco fans could backfire
The NFL seemingly took away a significant advantage for the San Francisco 49ers by scheduling head coach Kyle Shanahan's team to face the Los Angeles Rams in Melbourne, Australia, in Week 1. The 49ers have essentially benefited from two home games each season while playing the... -
Brock Purdy, Raheem Morris, Klay Kubiak preview 49ers vs. Rams clash in Australia
San Francisco 49ers defensive coordinator Raheem Morris and offensive coordinator Klay Kubiak spoke with reporters before Monday's (Tuesday in Melbourne) practice at AAMI Park as the team prepares for its Week 1 matchup against the Los Angeles Rams in Melbourne,... -
49ers practice in Melbourne without Nick Bosa, other injury notes
The San Francisco 49ers held their first practice of the week at AAMI Park in Melbourne, Australia, as the team prepares for its Week 1 matchup against the Los Angeles Rams. The most notable absence was star pass rusher Nick Bosa, who returned to practice last week after an... -
Kyle Shanahan reveals his thoughts on 49ers-Rams, Australia ahead of Week 1
San Francisco 49ers head coach Kyle Shanahan spoke with reporters before Sunday's (Monday in Melbourne) practice at AAMI Park as the team prepares for its Week 1 matchup against the Los Angeles Rams in Melbourne, Australia. Here's everything Shanahan had to say ahead of the...