The 49ers are coming off of a 27-20 win over the New York Giants while the Cardinals are coming off of a 21-17 win over the Philadelphia Eagles.
The game kicks off at 1:05 PM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on FOX.
In the 49erswebzone.com Pick 'Em Contest, 98% of 49ers fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 93% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.