The 49ers are coming off of a 19-11 win over the Washington Redskins while the Giants are coming off of a 24-20 win over the New England Patriots.
The game kicks off at 1:15 PM and, as usual, you can visit 49erswebzone.com for the latest news and updates during and after the game.
The game will be televised on FOX.
In the 49erswebzone.com Pick 'Em Contest, 87% of 49ers fans believe that the 49ers will win this game.
Within Sportstacular, a popular mobile phone scores application, 67% of fans believe that the 49ers will win this game.
You can follow the game live on NFL.com's Game Center.
You can also discuss the game with fans in the 49erswebzone.com forums.
More San Francisco 49ers News
-
49ers owner Jed York remains heavily involved despite absence
San Francisco 49ers owner Jed York was recently arrested in Ohio during a prostitution sting, leaving many wondering what his role with the team might look like moving forward. 49ers general manager John Lynch says York remains heavily involved with the organization, even if... -
Former 49ers player sounds off on Jed York's arrest
There are still many unanswered questions surrounding the arrest of San Francisco 49ers owner Jed York over the weekend. One of the biggest is the potential fallout from York's no-contest plea Monday morning to two misdemeanor charges: disorderly conduct and possessing criminal... -
Will Jed York regain his leadership role with the 49ers?
There is a pretty big question hanging over the San Francisco 49ers right now, and it has nothing to do with Brock Purdy, Kyle Shanahan, the new defense, or the roster. Instead, it's about the owner and who will be leading the team in the future. What exactly is Jed York's... -
49ers CEO Al Guido reportedly representing team at NFL meeting after Jed York arrest
NFL owners and designated team representatives gathered Wednesday at an Atlanta hotel to formally vote on the sale of the Seattle Seahawks. The sale was approved, while the league also addressed other issues. Normally, it's assumed that San Francisco 49ers owner Jed York would...