Cornerback Renardo Green left the game with a hamstring injury in the first half and did not return. Offensive lineman Austen Pleasants walked off the field in the second half after spending a few minutes on the turf with a knee injury, while linebacker Nick Martin sustained a hamstring injury before the game came to an end.
Shanahan didn't seem certain about the extent of Green's injury. Jack Jones replaced Green at cornerback Thursday night.
"We'll have to get more imaging on that tomorrow to see if he pulled it," Shanahan said.
Pleasants started the game at left tackle and was getting work at guard before he exited.
"It's not an ACL, but we've got to find out for sure exactly what it was tomorrow," Shanahan said.
Shanahan didn't provide any additional details on Martin's injury.
Shanahan also announced after the game that guard Robert Jones is sidelined with an unspecified injury. Jones did not play Thursday and could miss another week, according to Shanahan.
The 49ers will finish out their preseason schedule next Thursday with a road game against the Las Vegas Raiders. The game will kick off at 8 p.m. ET/5 p.m. PT at Allegiant Stadium in Las Vegas.
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