Inactives:
- RB Jordan James
- DL Jordan Jefferson
- LB Nick Martin
- OL Drew Moss
- OL Austen Pleasants
- QB Brock Purdy (left shoulder, toe)
- WR Jordan Watkins
On Friday, the 49ers officially ruled out quarterback Brock Purdy for the game against the Saints. Wide receiver Jauan Jennings (shoulder) and left tackle Trent Williams (knee) were listed as questionable, but both are active.
On Saturday, the 49ers announced several roster moves ahead of their Week 2 matchup. The team elevated tight end Brayden Willis and quarterback Adrian Martinez from the practice squad, while also promoting linebacker Curtis Robinson to the 53-man roster. To make room for the addition, the 49ers waived defensive end Robert Beal Jr.