Each week, 49ers Webzone staff members take part in the NFL Pick 'Em contest, predicting the winners of every NFL game. For Week 16, five out of seven participating staff members have picked the 49ers to defeat the Dolphins.
Among the fans participating in the NFL Pick 'Em contest, 67 percent are backing a 49ers victory, based on the latest poll results.
Most One-Sided Matchup: Patriots at Bills
The most lopsided prediction for Week 16 is Sunday's clash between the New England Patriots and the Buffalo Bills. An overwhelming 100 percent of fans are confident the Bills will secure the win. Buffalo is currently a 14-point favorite heading into the contest.
Most Competitive Matchup: Jaguars at Raiders
The tightest matchup of the week is Sunday's game between the Jacksonville Jaguars and the Las Vegas Raiders. In a near-even split, 54 percent of participants are picking the Jaguars to come out on top.
Week 16 NFL Matchups
Below is a breakdown of all 15 matchups for the upcoming slate of NFL games.
| Picks | Away | Home | Picks |
|---|---|---|---|
|
33%
|
Texans
|
Chiefs
|
67%
|
|
10%
|
Steelers
|
Ravens
|
90%
|
|
4%
|
Browns
|
Bengals
|
96%
|
|
4%
|
Giants
|
Falcons
|
96%
|
|
96%
|
Lions
|
Bears
|
4%
|
|
9%
|
Titans
|
Colts
|
91%
|
|
83%
|
Rams
|
Jets
|
17%
|
|
81%
|
Eagles
|
Commanders
|
19%
|
|
86%
|
Cardinals
|
Panthers
|
14%
|
|
91%
|
Vikings
|
Seahawks
|
9%
|
|
0%
|
Patriots
|
Bills
|
100%
|
|
54%
|
Jaguars
|
Raiders
|
46%
|
|
67%
|
49ers
|
Dolphins
|
33%
|
|
86%
|
Buccaneers
|
Cowboys
|
14%
|
|
1%
|
Saints
|
Packers
|
99%
|
More San Francisco 49ers News
-
49ers vs. Bears: 5 Key Players Who Can Decide San Francisco's Week 17 Clash
Clinching a playoff spot before playing a game must be nice! That's exactly what happened during Week 16, before the San Francisco 49ers defeated the Indianapolis Colts 48-27. The win earned quarterback Brock Purdy NFC Player of the Week honors with a scintillating 295-yard,... -
49ers in free agency: 5 wide receivers who can replace Brandon Aiyuk
Before their win Monday night over Indianapolis, the San Francisco 49ers had officially clinched a playoff spot. Pittsburgh defeated Detroit in Week 16, making the NFC playoff picture clearer with two weeks to go in the regular season. This has been one of head coach Kyle... -
49ers open as slight favorites in Week 18 showdown with Seahawks
There's plenty at stake Saturday night when the San Francisco 49ers host the Seattle Seahawks at Levi's Stadium. The winner not only claims the NFC West crown but also secures the No. 1 seed in the NFC playoffs and home-field advantage. For the 49ers, that top seed would be... -
49ers vs. Seahawks: NFL insider suggests Trent Williams may miss Week 18
The San Francisco 49ers may be without left tackle Trent Williams—quarterback Brock Purdy's most trusted protector—when they face the Seattle Seahawks on Saturday night at Levi's Stadium. The Week 18 matchup will decide the NFC West champion and the NFC's No. 1 seed, giving...