The Miami Dolphins will host the San Francisco 49ers at Hard Rock Stadium in Miami Gardens, Florida, on Sunday, December 22, at 1:25 p.m. PT. The Dolphins enter the game as slight favorites, with a one-point edge according to the latest odds.

Each week, 49ers Webzone staff members take part in the NFL Pick 'Em contest, predicting the winners of every NFL game. For Week 16, five out of seven participating staff members have picked the 49ers to defeat the Dolphins.


Among the fans participating in the NFL Pick 'Em contest, 67 percent are backing a 49ers victory, based on the latest poll results.

Most One-Sided Matchup: Patriots at Bills


The most lopsided prediction for Week 16 is Sunday's clash between the New England Patriots and the Buffalo Bills. An overwhelming 100 percent of fans are confident the Bills will secure the win. Buffalo is currently a 14-point favorite heading into the contest.

Most Competitive Matchup: Jaguars at Raiders


The tightest matchup of the week is Sunday's game between the Jacksonville Jaguars and the Las Vegas Raiders. In a near-even split, 54 percent of participants are picking the Jaguars to come out on top.

Week 16 NFL Matchups


Below is a breakdown of all 15 matchups for the upcoming slate of NFL games.

Picks Away Home Picks
33%
Texans
Chiefs
67%
10%
Steelers
Ravens
90%
4%
Browns
Bengals
96%
4%
Giants
Falcons
96%
96%
Lions
Bears
4%
9%
Titans
Colts
91%
83%
Rams
Jets
17%
81%
Eagles
Commanders
19%
86%
Cardinals
Panthers
14%
91%
Vikings
Seahawks
9%
0%
Patriots
Bills
100%
54%
Jaguars
Raiders
46%
67%
49ers
Dolphins
33%
86%
Buccaneers
Cowboys
14%
1%
Saints
Packers
99%


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