Inactives:
- RB Israel Abanikanda
- G Aaron Banks (concussion)
- DE Nick Bosa (hip, oblique)
- QB Joshua Dobbs
- LB Demetrius Flannigan-Fowles (knee)
- T Trent Williams (ankle)
- CB Rock Ya-Sin
Several players were officially ruled out on Friday, including left tackle Trent Williams, who will miss his third consecutive game due to an ankle injury.
Linebacker Dre Greenlaw remains on the physically unable to perform (PUP) list as he works his way back from a torn Achilles. There is optimism he could be activated ahead of Thursday's game against the Los Angeles Rams.
On Saturday, the 49ers placed two players on injured reserve: running back Jordan Mason and safety George Odum. Mason suffered a high-ankle sprain during last week's game against the Buffalo Bills, while Odum sustained a knee injury during practice last week.
Additionally, the 49ers downgraded two key players to "out" on Saturday. Defensive end Nick Bosa, initially listed as doubtful, will miss his third straight game as he deals with hip and oblique injuries. Left guard Aaron Banks, who remains in the concussion protocol, was initially questionable but has also been ruled out.
In response to these roster challenges, the 49ers made several adjustments on Saturday. Offensive lineman Sebastian Gutierrez was promoted from the practice squad to the active roster. Linebacker Jalen Graham and running back Ke'Shawn Vaughn were elevated from the practice squad.
Recently acquired running back Israel Abanikanda will not be active for the game. The 49ers' available running backs will be Isaac Guerendo, Patrick Taylor, and Ke'Shawn Vaughn. Additionally, linebacker Demetrius Flannigan-Fowles, who was questionable with a knee injury, has also been ruled inactive.
In a positive development, safety Talanoa Hufanga was activated from injured reserve. He is set to return to action after recovering from a wrist injury.
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