San Francisco 49ers
Out
G Aaron Banks (concussion), DE Nick Bosa (hip, oblique), DT Jordan Elliott (concussion), LB Dre Greenlaw (Achilles), CB Deommodore Lenoir (knee), T Trent Williams (ankle)
Questionable
WR Chris Conley (knee), LB Demetrius Flannigan-Fowles (knee), DT Kevin Givens (groin), CB Renardo Green (neck), QB Brock Purdy (right shoulder)
Buffalo Bills
Out
T Tylan Grable (groin), TE Dalton Kincaid (knee)
Questionable
DT DeWayne Carter (wrist), WR Keon Coleman (wrist), LB Matt Milano (biceps)
Injury Notes
Quarterback Brock Purdy was seen throwing during Friday's practice, a significant step forward after limited activity during Wednesday's session. Thursday's practice was closed to the media due to the Thanksgiving holiday.
Purdy is working his way back from a shoulder injury sustained in Week 11 against the Seattle Seahawks and is officially listed as questionable for Sunday's game. However, head coach Kyle Shanahan stated that he expects Purdy to play.
"Brock wouldn't be playing if he wasn't 100% at it," Shanahan said. "So, I think the fact that he's going to be playing means he's healthy."
Meanwhile, tackle Trent Williams, defensive end Nick Bosa, guard Aaron Banks, and cornerback Deommodore Lenoir were among the players absent from Friday's practice. All four were ruled out for Sunday's game.
Shanahan noted that the 49ers aren't sure when Bosa or Williams might return.
"We understand kind of what's wrong with them," Shanahan said. "It's just kind of how it heals. And the guys, Trent especially, hasn't been healing the way we hoped. Hopefully, they got a better chance next week, but they ended up never getting back into practice this week, so ended up not being that close."
Lenoir is dealing with a deep knee bone bruise. Shanahan commented, "It's kind of like a quad contusion, but it's right on the bone. ... Tried to go all week, and just couldn't get it to go."
Cornerback Charvarius Ward did not appear on the game status report and is expected to return this weekend. He has not played since Week 8.
Below are Friday's practice participation reports for both the 49ers and Bills, which were provided by the 49ers Communications staff.
San Francisco 49ers Friday Practice
Did Not Participate In Practice
G Aaron Banks (concussion), DE Nick Bosa (hip, oblique), DT Jordan Elliott (concussion), CB Deommodore Lenoir (knee), T Trent Williams (ankle)
Limited Participation in Practice
LB Dre Greenlaw (Achilles), WR Chris Conley (knee), LB Demetrius Flannigan-Fowles (knee), DT Kevin Givens (groin), CB Renardo Green (neck)
Full Participation in Practice
QB Brock Purdy (right shoulder), RB Christian McCaffrey (not injury related - resting player), G Dominick Puni (shoulder), WR Jacob Cowing (concussion), CB Charvarius Ward (not injury related - personal matter)
Buffalo Bills Friday Practice
Did Not Participate In Practice
TE Dalton Kincaid (knee)
Limited Participation in Practice
WR Keon Coleman (wrist)
Full Participation in Practice
T Tylan Grable (groin), DT DeWayne Carter (wrist), LB Matt Milano (biceps), T Spencer Brown (ankle), LB Terrel Bernard (ankle), WR Amari Cooper (wrist), CB Kaiir Elam (shoulder), FB Reggie Gilliam (hip), WR Mack Hollins (shoulder), DT DaQuan Jones (foot), TE Quintin Morris (shoulder), S Taylor Rapp (foot, shoulder), WR Curtis Samuel (pectoral), DE Casey Toohill (knee), LB Dorian Williams (knee)
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