Samuel unexpectedly returned to practice on Thursday, sparking hope that he could suit up this weekend against the New England Patriots.
"When we have these injuries, there's timelines based upon scans and MRIs and data that we've collected over long periods of time," general manager John Lynch said Friday morning during his weekly interview on Bay Area radio station KNBR. "That probably has changed from when I played. They give a timeline, and it probably errs on the side of caution because the data tells you if you bring them back too soon, you run the risk of them being hurt more, more severe injuries.
"But they're just that; they're timelines. And so, Deebo ... the best athletes seem to heal at a little better rate. But we have really objective testing and markers that they have to hit, and the reason he's on the field is because he hit all these markers, and he felt good enough to be out there."
Lynch noted that Thursday's practice is typically the most intense of the week, and the team will assess how Samuel feels on Friday before making any decisions.
"If he's ready, if he's hit all the markers, that would be a really nice surprise to have him back," Lynch added. "But I think that is to be determined here. Today will be a big day in that process."
Samuel, now in his sixth NFL year, has 13 receptions for 164 yards through two games this season.
You can listen to Lynch's entire interview below.
More San Francisco 49ers News
-
John Lynch: Safe to say Brandon Aiyuk has played last snap with 49ers
Speculation has surrounded the future of San Francisco 49ers wide receiver Brandon Aiyuk for months, and on Wednesday, general manager John Lynch all but confirmed what many in the media expected. Aiyuk, who did not return this season after suffering ACL and MCL injuries in... -
49ers end-of-season press conference: John Lynch, Kyle Shanahan to speak Wednesday
San Francisco 49ers general manager John Lynch and head coach Kyle Shanahan will hold their annual end-of-season press conference on Wednesday, January 21, at 11:30 a.m. (PT), offering insight into the team's plans for the upcoming offseason. The availability will allow local... -
Kyle Shanahan, John Lynch hold 49ers end-of-season press conference
San Francisco 49ers head coach Kyle Shanahan and general manager John Lynch held their annual end-of-season press conference on Wednesday, reflecting on the team's 2025 campaign, which ended in the Divisional Round of the playoffs. Here is everything they said. Transcript... -
49ers' John Lynch on Jauan Jennings: "We'd love to have him back"
San Francisco 49ers wide receiver Jauan Jennings' future remains uncertain. After expressing frustration over his contract last year, the team restructured the final year of his deal, allowing the fan-favorite to earn additional incentives. Jennings is set to become a free...