Tight end George Kittle is missing practice due to a hamstring injury, while cornerback Charvarius Ward is dealing with both hamstring and knee issues.
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"With no practice today, his status for Sunday's game vs. the Rams is in question," ESPN's Adam Schefter wrote of Kittle's absence.
Thursday marks the second practice of the week, with one more scheduled for Friday before the 49ers travel to Southern California for their NFC West showdown against the Los Angeles Rams. Several star contributors may be unavailable for this divisional clash.
The Rams are also grappling with injury concerns. Star receivers Cooper Kupp (ankle) and Puka Nacua (PCL sprain) will be unavailable this weekend, and the team is dealing with multiple injuries along the offensive line.
The 49ers, sitting at 1-1 after a loss to the Minnesota Vikings, face a Rams team still searching for its first win of the season. The Rams are 0-2, following a 41-10 defeat to the Arizona Cardinals.
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