Below are the 49ers-related in-game injury updates.
S Talanoa Hufanga (knee, out)
In the third quarter, Talanoa Hufanga exited the game and proceeded to the medical tent for additional evaluation. After an extended period in the tent, the safety was carted to the locker room.
The 49ers ruled Hufanga out with a knee injury. He was replaced by rookie Ji'Ayir Brown.
Update: The 49ers fear Hufanga suffered an ACL injury and will learn more on Monday.