Only NFL tight ends Kellen Winslow, Travis Kelce, and Jimmy Graham reached the mark in fewer games.
San Francisco made Kittle (6-4, 250) a fifth-round selection (No. 146 overall) out of Iowa in 2017. Entering Sunday's contest, the 29-year-old tight end had 398 receptions for 5,273 yards and 31 touchdowns in 83 game appearances (75 starts), per Pro Football Reference.
Kittle was named a first-team All-Pro in 2019 and is a four-time Pro Bowl selection.